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Components of Blood • Whole blood – RBCs – WBCs – Platelets: cell fragments that aid in clotting • Plasma – 90% water (allows materials to dissolve) – Amino acids, glucose, hormones, vitamins, salts, waste – Concentrations allows diffusion in/out of blood stream Click picture to play Red Blood Cells • • • • • Produced from stem cells in bone marrow Lose nucleus as they mature Transport O2 to cells; remove CO2 O2 binds to hemoglobin proteins Dead cells filtered by liver & spleen Sickle Cell Normal ABO Blood Groups • Proteins on blood cells determine blood type • Antigen – proteins on cells that identify cells as foreign or natural – on the surface of RBCs • Antibodies: – proteins from WBCs to attack invaders – in the blood plasma Group A blood • A antigens on the surface of your RBCs • B antibodies in your blood plasma Group B blood • B antigens on the surface of your RBCs • A antibodies in your blood plasma Group AB blood • A and B antigens on the surface of your RBCs • no A or B antibodies at all in your blood plasma Group O blood • No A or B antigens on the surface of your RBCs • both A and B antibodies in your blood plasma Rh Factors • Rh+ – Protein found in blood – Can receive Rh+ or Rh- blood • Rh– Lack protein in blood – Only receive Rhblood Francis was just in a bad accident and lost a lot of blood. He is blood type B+. Can you help save him? Blood type B+ Antigens: Which does he have? A B Rh Antibodies: Which does he have? A B Rh B+ This person has B+ blood type because of the B and Rh antigens B antigens Rh antigens Can he accept B+ blood? Yes. The A antibodies do not have A antigens to attack. Therefore, no attacking and clumping of blood cells will occur. Vein B+ B antigens Rh antigens B+ B antigens Rh antigens A antibody B+ A antibody A antibody B antigens Rh antigens This person has B+ blood type because of the B and Rh antigens BB antigens Can he accept B- blood? Yes. The A antibodies do not have A antigens to attack. Therefore, no attacking and clumping of blood cells will occur. Vein B+ B antigens Rh antigens B+ B antigens Rh antigens A antibody B+ A antibody A antibody B antigens Rh antigens A+ This person has B+ blood type because of the B and Rh antigens A antigens Rh antigens Can he accept A+ blood? No. The A antibodies will attack the A antigens. This will cause the blood cells to clump, thus stopping blood flow. This person may die. Vein B+ B antigens Rh antigens B+ B antigens Rh antigens A antibody B+ A antibody A antibody B antigens Rh antigens This person has B+ blood type because of the B and Rh antigens AA antigens Can he accept A- blood? No. The A antibodies will attack the A antigens. This will cause the blood cells to clump, thus stopping blood flow. This person may die. Vein B+ B antigens Rh antigens B+ B antigens Rh antigens A antibody B+ A antibody A antibody B antigens Rh antigens AB+ This person has B+ blood type because of the B and Rh antigens A antigens B antigens Rh antigens Can he accept AB+ blood? No. The A antibodies will attack the A antigens. This will cause the blood cells to clump, thus stopping blood flow. This person may die. Vein B+ B antigens Rh antigens B+ B antigens Rh antigens A antibody B+ A antibody A antibody B antigens Rh antigens AB- This person has B+ blood type because of the B and Rh antigens A antigens B antigens Can he accept AB- blood? No. The A antibodies will attack the A antigens. This will cause the blood cells to clump, thus stopping blood flow. This person may die. Vein B+ B antigens Rh antigens B+ B antigens Rh antigens A antibody B+ A antibody A antibody B antigens Rh antigens This person has B+ blood type because of the B and Rh antigens O+ Rh antigens antigens Can he accept O+ blood? Yes. The A antibodies do not have A antigens to attack. Therefore, no attacking and clumping of blood cells will occur. Vein B+ B antigens Rh antigens B+ B antigens Rh antigens A antibody B+ A antibody A antibody B antigens Rh antigens This person has B+ blood type because of the B and Rh antigens ONo antigens antigens Can he accept O- blood? Yes. The A antibodies do not have A antigens to attack. Therefore, no attacking and clumping of blood cells will occur. Vein B+ B antigens Rh antigens B+ B antigens Rh antigens A antibody B+ A antibody A antibody B antigens Rh antigens Sebastian was just involved in an accident at work and lost a lot of blood. He is blood type A-. Can you help save him? Blood type AAntigens: Which does he have? A B Rh Antibodies: Which does he have? A B Rh This person has A- blood type because of the A antigen A-AAA A antigens A antigens antigens Can he accept A- blood? Yes. The B and Rh antibodies do not have antigens to attack. Therefore, no attacking and clumping of blood cells will occur. A- Rh antibody A antigens A- AA antigens B antibody B antibody A antigens Rh antibody This person has A- blood type because of the A antigen A+ A+ A antigens A antigens A+ Rh ARh antigens antigens antigens Rh antigens Can he accept A+ blood? No. The Rh antibodies will attack the Rh antigens. This will cause the blood cells to clump, thus stopping blood flow. This person may die. A- Rh antibody A antigens A- AA antigens B antibody B antibody A antigens Rh antibody This person has A- blood type because of the A antigen B-BBBB antigens antigens B antigens Can he accept B- blood? No. The B antibodies will attack the B antigens. This will cause the blood cells to clump, thus stopping blood flow. This person may die. A- Rh antibody A antigens A- AA antigens B antibody B antibody A antigens Rh antibody This person has A- blood type because of the A antigen B+ B+ B+ B antigens B antigens BRh antigens Rh Rh antigens antigens antigens Can he accept B+ blood? No. Both B and Rh antibodies will attack the B and Rh antigens. This will cause the blood cells to clump, thus stopping blood flow. This person may die. A- Rh antibody A antigens A- AA antigens B antibody B antibody A antigens Rh antibody This person has A- blood type because of the A antigen ABABA antigens AABantigens BAantigen Bantigens antigen B antigen Can he accept AB- blood? No. The B antibodies will attack the B antigens. This will cause the blood cells to clump, thus stopping blood flow. This person may die. A- Rh antibody A antigens A- AA antigens B antibody B antibody A antigens Rh antibody This person has A- blood type because of the A antigen AB+ AB+ AB+ A antigens A antigens A antigens B antigens B antigens B Rh antigens Rh Rh antigens antigens antigens Can he accept AB+ blood? No. Both B and Rh antibodies will attack the B and Rh antigens. This will cause the blood cells to clump, thus stopping blood flow. This person may die. AA antigens Rh antibody A- AA antigens B antibody B antibody A antigens Rh antibody This person has A- blood type because of the A antigen O-ONoONo antigens antigens No antigens Can he accept O- blood? Yes. The antibodies do not have antigens to attack. Therefore, no attacking and clumping of blood cells will occur. AA antigens Rh antibody A- AA antigens B antibody B antibody A antigens Rh antibody This person has A- blood type because of the A antigen O+ O+ Rh Rh O+ antigens antigens Rh antigens Can he accept O+ blood? No. Rh antibodies would attack the Rh antigens and cause clumping. AA antigens Rh antibody A- AA antigens B antibody B antibody A antigens Rh antibody Blood type AB+ Antigens: Which does they have? A B Rh Antibodies: Which does they have? A B Rh Blood type O+ Antigens: Which does they have? A B Rh Antibodies: Which does they have? A B Rh Blood type ABAntigens: Which does they have? A B Rh Antibodies: Which does they have? A B Rh Blood type B+ Antigens: Which does they have? A B Rh Antibodies: Which does they have? A B Rh Blood type OAntigens: Which does they have? A B Rh Antibodies: Which does they have? A B Rh White Blood Cells • Remove foreign invaders & dead cells • Able to move through body tissue Platelets • Form clots when bleeding • Proteins form a web to trap cells & platelets