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KEY CONCEPT Blood is a complex tissue that transports materials. Blood is composed mainly of cells, cell fragments, and plasma. • Whole blood is made up of different materials. – Plasma • 90% H2O- allows for materials to dissolve • Concentrations- diffusion into or out of blood plasma • Amino acids, glucose, salts, waste, vitamins, hormones – red blood cells – white blood cells – platelets red blood cells, white blood cells, and platelets Red Blood Cells • • • • • Produced from stem cells in bone marrow Lose nucleus as they mature Transport O2 to cells; remove CO2 O2 binds to hemoglobin proteins Dead cells filtered by liver & spleen • White blood cells fight pathogens and destroy foreign matter. red blood cell platelet white blood cell • Platelets help form clots that control bleeding. platelets fibrin red blood cell white blood cell ABO Blood Groups • Proteins on blood cells determine blood type • Antigens (markers) – proteins on cell’s surface that identify cells as foreign or natural • Antibodies: – proteins from WBCs to attack invaders • Will bind to foreign blood types and cause clumps – Float freely in plasma Group A blood • A antigens on the surface of your red blood cells and B antibodies in your blood plasma Group B blood • B antigens on the surface of your red blood cells and A antibodies in your blood plasma Group AB blood • A and B antigens on the surface of your red blood cells and no A or B antibodies at all in your blood plasma Group O blood • No A or B antigens on the surface of your red blood cells but you have both A and B antibodies in your blood plasma Rh Factors • Rh Factor is another protein found on blood (like the A and B antigens). • Rh+ (A+, B+, AB+, O+) – You have the Rh factor protein in blood – Can receive Rh+ or Rhblood (if you have Rh proteins, but are given blood without it, your body will just make more) • Rh- (A-, B-, AB-, O-) – You don’t have the Rh factor protein in blood – Only receive Rh- blood 1) Can this work? • Acceptor • Donor O- AB- 2) Can this work? • Acceptor • Donor A+ A- 3) Can this work? • Acceptor • Donor AB- B-