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Biochemical Evolution Prebiotic World What had to happen before life could exist on earth? What kinds of molecules may have been present in earth’s early atmosphere? – – – – Methane Ammonia Hydrogen Water Biochemical Macromolecules What did Miller and Urey do to find out whether complex organic molecules could have formed spontaneously? Biological Macromolecules Products of Urey-Miller Experiment Biological Macromolecules Evolution What characterizes evolving systems? – Ability to replicate – Variation – Competition Molecular Evolution How did Spiegelman demonstrate molecular evolution in a test tube? Molecular Evolution What are ribozymes and what have they contributed to our ideas about evolution? Molecular Evolution How can amino acids play both synthetic and catalytic roles? Molecular Evolution How does the variation needed for evolution come to exist? Molecular Evolution What advantages does DNA have over RNA as the genetic storehouse? – 2-deoxyribose not suscetible to hydrolytic cleavage – Methyl group of thymine contributes to DNA repair Energy & Living Systems What is the role of ATP and how is it made in cells? Energy & Living Systems What is the nature of the cell membrane and how does it affect the contents of the cell? Energy & Living Cells How did evolving cells deal with the harmful effects of osmosis? Energy & Living Cells How are proton gradients used inside of cells? Energy & Living Cells What biochemical process evolved first, photosynthesis or respiration? Cells Respond to Environmental Change In what ways do cells sense changes in their environment? What enables cells to respond? Cells Respond to Environmental Change What enables cells to move? Cells Respond to Environmenmtal change Under what conditions do individual cells form colonies? Cells Respond to Environmental Change What can we learn by studying simple organisms like the worm C. elegans?