Download Proteins

Proteins
Regents Biology
Proteins:
Multipurpose Molecules
Regents Biology
2006-2007
Proteins
Examples


muscle
skin, hair, fingernails, claws
 collagen, keratin

insulin
pepsin
pepsin
 digestive enzyme
in stomach

insulin
 hormone that controls blood
sugar levels
Regents Biology
collagen (skin)
Proteins
 Function:

many, many functions
 hormones
 signals from one body system to another
 insulin
 movement
 muscle
 immune system
 protect against germs
 enzymes
Regents Biology  help chemical reactions
Proteins
 Building block = amino acids
amino amino amino amino amino
acid – acid – acid – acid – acid

20 different amino acids
H O
H
| ||
—N—
—C—C—OH
|
H variable
Regents Biology
group
There’s
20 of us…
like 20 different
letters in an
alphabet!
Can make lots of
different
words
Dipeptide = two amino acids
bonded by a condensation reaction
 Covalent bond called a
Peptide Bond shown in lavender (?)
Regents Biology
Proteins = Polypeptides
 Polypeptide = Long amino acid
chains… composed mainly of carbon,
hydrogen, oxygen, and nitrogen
Regents Biology
Amino acid chains
 Proteins = amino acids chained into a
polymer
amino acid
amino acid
amino acid
amino acid
amino acid
 Each amino acid is different

some “like” water & dissolve in it

some “fear” water & separate from it
Regents Biology
Water-fearing amino acids
 Hydrophobic
“water fearing” amino acids
 try to get away from water in cell

 the protein folds
Regents Biology
Water-loving amino acids
 Hydrophillic
“water loving” amino acids
 try to stay in water in cell

 the protein folds
Regents Biology
For proteins: SHAPE matters!
 Proteins fold & twist into 3-D shape

that’s what happens in the cell!
 Different shapes = different jobs
growth
hormone
Regents Biology
hemoglobin
pepsin
collagen
It’s SHAPE that matters!
 Proteins do their jobs, because
of their shape
 Unfolding a protein destroys its shape
wrong shape = can’t do its job
 unfolding proteins = “denature”

 temperature
unfolded
“denatured”
 pH (acidity)
In Biology,
it’s not the size,
it’s the SHAPE
that matters!
Regents Biology
folded
Regents Biology
Let’s EAT some
Proteins!
Regents Biology
2006-2007