Download Fatty Acid & Protein Metabolism

Fatty Acid & Protein
Metabolism
Carbohydrate metabolism
is WAY groovy baby!
But what does Jon expect
us to know from all this
chemistry mumbo jumbo?
Where is Carbohydrate Metabolism?
• Glycolysis
___________________
• Krebs Cycle
___________________
• ETS
___________________
When Is Oxygen Required?
• Glycolysis
_________________
• Krebs Cycle
_________________
• ETS
_________________
What is Produced?
• Glycolysis
__________________
• Krebs Cycle
__________________
• ETS
__________________
Outline
I. Anaerobic Metabolism
II. Fat Metabolism
A. Ketoacidosis
B. Diabetes Mellitus
III. Protein Metaboism
Aerobic vs. Anaerobic Respiration
• Only gylcolysis can
occur without O2
Aerobic vs. Anaerobic Respiration
• Only gylcolysis can
occur without O2
• Anaerobic
Metabolism:
1. Inefficient and
cannot be
sustained for
long periods
Anaerobic Metabolism
• Occurs during
strenuous exercise
• O2 cannot be
delivered to cells fast
enough for Krebs
Cycle
Outline
I. Anaerobic Metabolism
II. Fat Metabolism
A. Ketoacidosis
B. Diabetes Mellitus
III. Protein Metaboism
You Don’t Just Eat Carbohydrates
Big Mac Nutrition Facts:
Calories
Protein (g)
Carbohydrates (g)
Total Fat (g)
Saturated Fat (g)
Sodium (mg)
500
25
42
26
16
890
You Don’t Just Eat Carbohydrates
Big Mac Nutrition Facts:
Calories
Protein (g)
Carbohydrates (g)
Total Fat (g)
Saturated Fat (g)
Sodium (mg)
500
25
42
26
16
890
Structure of Triglycerides
Metabolism of Fats
• Fats broken into parts
that enter glycolysis and
Kreb’s cycle
Metabolism of Fats
• Fats broken into parts
that enter glycolysis and
Kreb’s cycle
• Fats and Carbohydrates
can be stored
You Need Some Carbs to Burn Fat
“Fats Burn in the Fire of Carbohydrate Metabolism”
2 Carbon
6 Carbon
4 Carbon
Without Glucose, Ketoacidosis Occurs
Example:
Acetone
Metabolic Disorder: Diabetes Mellitus
• Ketoacidosis occurs in Type I Diabetes
Metabolic Disorder: Diabetes Mellitus
• Ketoacidosis occurs in Type I Diabetes
• Lack of insulin causes hyperglycemia
Metabolic Disorder: Diabetes Mellitus
• Ketoacidosis occurs in Type I Diabetes
• Lack of insulin causes hyperglycemia
• Dehydration and sweet taste to urine
Dangers of Ketoacidosis
• Blood pH drops
• Fruity smell to breath
• Diabetic Coma
• Death results
Outline
I. Anaerobic Metabolism
II. Fat Metabolism
A. Ketoacidosis
B. Diabetes Mellitus
III. Protein Metabolism
Protein Metabolism
• Last resort for energy
• Why might this be?
Protein Metabolism
• Most is converted into
glucose
Protein Metabolism
• Most is converted into
glucose
• Some broken down
into Urea
Summary
• Carbohydrates, Fats, and proteins are all
used for energy (in that order)
• Without oxygen, pyruvate is converted to
lactate
• Ketoacidosis occurs in diabetics lacking
glucose metabolism