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NARCAN OVERVIEW Narcan Classification—Synthetic opioid antagonist Mechanism—Competes for opioid receptor sites. Displaces previously administered opioids from their receptors. Indications—Opioid induced collapse; hemodynamic instability and respiratory depression -Cardiovascular collapse with airway compromise and a differential diagnosis of drug abuse Narcan Contraindications—Hypersensitivity to Naloxone (Morphine-like opioids) Dose--Unconscious/overdose: 0.4 mg IV or 0.8 mg SC Route and Methods of Administration—IV push; repeat as indicated (per protocol) SC; repeat as indicated (per protocol) Narcan Onset, Duration—Less than 2 minutes 30 to 60 minutes (IV) Elimination—Liver; half-life of 60 to 90 minutes (IV) Narcan Side Effects: CNS--Excitation due to abrupt reversal of analgesia -Tremulousness CVS—Tachycardia -Hypertension -Arrhythmias Skin--Sweating Narcan Special Considerations Can cause abrupt state of narcotic withdrawal in the physically dependent patient. Side effects such as agitation and aggressiveness can be symptoms of narcotic withdrawal. Naloxone's half-life (60 to 90 minutes) is shorter than that of all opioids; therefore, a patient must be observed until the narcotic effect has worn off. All patients treated with Naloxone must be transported to hospital Commonly Abused Opiates Codeine Heroin Hydromorphone (Dilaudid) Morphine Fentanyl Demerol Opium Amileridine (Leritine) Pentayocine (Talwin) Methadone Percocet (Percodan)