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Naloxone (Narcan) Drug Information Classification Pharmacology Indications Contraindications Precautions Warnings Dose Route of Administration Onset Duration of Action Metabolism and Excretion Storage and Stability Opioid antagonist Prevents or reverses the effects of opioids by blocking the κ, σ and μ opioid receptor sites in the central nervous system respiratory depression sedation hypotension Has no pharmacological effect in the absence of opioids: produces withdrawal symptoms Acute opioid overdose or complete or partial reversal of opioid depression: respiratory depression Hypersensitivity to naloxone or any ingredient in the formulation o naloxone hydrochloride o methylparaben o propylparaben Naloxone should be used with caution in clients with pre-existing cardiac disease or in clients receiving potentially cardiotoxic drugs. Reports of hypotension, hypertension, ventricular fibrillation, ventricular tachycardia, and pulmonary edema have been reported in post-operative patients receiving naloxone. Pregnancy Data is limited regarding the effects of naloxone on the fetus. Pregnancy is not a contraindication for naloxone administration. Lactation/Breast-Feeding It is not known whether naloxone is excreted into human breast milk. Consideration of the risks and benefits of administration should be applied. Initial dose of 0.4mg followed by a repeat 0.4mg dose every 2 minutes prn. Each THN Kit contains two 0.4mg/mL vials. Intramuscular (IM) or Subcutaneous (SC) 2-5 minutes Depends on the route of administration and can range from 30–120 minutes. Individuals treated with naloxone should go to the Emergency Department. Rapidly metabolized in the liver with a half-life of 30–60 minutes in adults. Excreted in the urine. Store between 15–30°C and protect from light. Keep out of reach of children. This resource tool has been adapted for use with permission from the B.C. Centre for Disease Control Harm Reduction Program