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At CardioNet: Investor Relations 1.800.908.7103 [email protected] CardioNet, Inc. Glossary of Terms ablation – a therapeutic method in which a form of energy is used to physically destroy a small section of damaged heart tissue that is a source of abnormal electrical activity causing or contributing to some types of tachycardia (fast heartbeat). American Heart Association (AHA) – an organization whose mission is to fight heart disease and stroke. Additional information is available on the AHA website at www.americanheart.org. antiarrhythmic medication – a group of drugs that helps control and slow heart rate by either suppressing (slowing) the activity of tissue that is initiating electrical impulses too quickly in the SA node, or by slowing the transmission of fast electrical impulses inside the heart. Antiarrhythmics include several classes of drugs such as sodium channel blockers, beta-blockers, potassium channel blockers, calcium channel blockers, adenosine, and digitalis (also called digoxin and digitoxin). anticoagulant – a drug that decreases the ability of the blood to clot, or coagulate; sometimes called a blood thinner, although they do not actually thin the blood. They are used to treat certain blood vessel, heart and lung conditions. They are also given to certain people at high risk for forming blood clots, such as those with artificial heart valves or who have atrial fibrillation. Anticoagulants do not dissolve clots but may prevent existing clots from becoming larger and causing more serious problems, and are often prescribed to prevent first or recurrent heart attack or stroke. arrhythmia – a disturbance in the normal rate and rhythm of the heart. atrial fibrillation – a disorder of heart rate and rhythm in which the heart’s two small, upper chambers (atria) quiver rapidly and empty blood into the heart’s lower chambers (ventricles) in a disorganized manner instead of beating effectively. Blood that isn’t pumped completely out of the atria when the heart beats may pool and clot. If a piece of a clot enters the bloodstream, it may lodge in the brain causing a stroke (ischemic stroke). atrial flutter – very rapid beating of the heart's upper chambers (atria). This rhythm occurs most often in people with heart diseases such as pericarditis, coronary artery disease and cardiomyopathy. Atrial flutter is typically not a stable rhythm and often degenerates into atrial fibrillation. CardioNet, Inc. Glossary Page 2 atrium – one of the two upper chambers of the heart that receive blood from the veins and in turn force it into the ventricles. bradycardia – a heart rate of less than 60 beats per minute. cardiac electrophysiologist – see electrophysiologist. cardiologist – a specialist in the structure, function, and disorders of the heart. congestive heart failure (CHF) – the state in which ineffective pumping of the heart results in a buildup of fluid in the lungs and elsewhere in the body. It does not mean the heart has stopped working altogether. Different diseases can cause the condition, including coronary artery disease, heart attacks and diseased heart valves. Common warning signs and symptoms include: fatigue, shortness of breath, and swelling or pain in the abdomen or lower limbs. Also referred to as heart failure. coronary artery bypass graft (CABG) – a heart surgery that creates new routes around narrowed and blocked arteries, allowing sufficient blood flow to deliver oxygen and nutrients to the heart muscles. dyspnea – shortness of breath, difficult or labored breathing. echocardiogram –a technique that uses a hand-held device (transducer) to send sound waves (like sonar) into the chest to rebound from the heart's walls and valves. The recorded waves show the shape, texture, and movement of the valves. They also show the size of the heart chambers and how well they're working. electrocardiogram (ECG or EKG) – measures the timing and duration of each electrical phase of a heartbeat. During an ECG, sensors (electrodes) that can detect the electrical activity of the heart are attached to the chest and sometimes to a person’s limbs. electrophysiologist – cardiologists who have specialized training in the heart's electrical system. They specialize in diagnosing and treating heart rhythm problems (arrhythmias) such as atrial fibrillation. event monitor – a device used by patients for 30 days to record the heart’s electrical activity. fibrillation – fast, uncoordinated contractions of individual heart muscle fibers. The heart chamber involved can’t contract all at once and pumps blood ineffectively, if at all. heart block – when the normal electrical impulses that make the heart function properly become impaired or don’t transmit while traveling from the upper to lower chambers of the heart. heart rhythm – the coordinated rhythmic pattern of electrical activity and/or muscle contractions in the heart. Heart Rhythm Society (HRS) – an organization whose mission is to improve the care of patients by promoting research, education and optimal health care policies and standards. Additional information is available on the HRS website at www.hrsonline.org. CardioNet, Inc. Glossary Page 3 hyper – prefix meaning “high.” hypo – prefix meaning “low.” Holter monitor – a portable ECG device that can be worn for 24-48 hours to record the heart's activity. long QT syndrome – an acquired or inherited condition, which may be triggered by one or a combination of more than 50 commonly used drugs. These drugs affect the heart's electrical function. On an electrocardiogram, the letter Q marks the point where an electrical impulse signals the ventricles to contract. The letter T marks the point where the cells of the ventricles have electrically recharged for the next heartbeat. When the QT interval is prolonged, ventricle cells may not have recovered in time to properly conduct the next heartbeat. People with long QT syndrome are prone to palpitations and fainting spells, and may have an increased risk of sudden death. mobile cardiac outpatient telemetry (MCOT) – a CardioNet service that allows doctors to capture significant arrhythmic events or definitively verify that no arrhythmic event occurred over a period of up to 21 days. Common applications include primary cardiac diagnostics, postprocedure monitoring, and drug titration for heart rate control medications. palpitations – the sensation of the heart beating rapidly or irregularly. premature contractions – defined as extra, early, or "skipped" beats. These beats are the most frequent cause of irregular heart rhythms. They can start in the upper or lower chambers of the heart. presyncope – symptoms such as dizziness, nausea, stomachache, chest pain, shortness of breath, or sweating that occur prior to a syncopal event. sick sinus – a condition that occurs if the pacemaking sinus node isn't sending impulses properly. The heart rate may be too slow, or it may speed up and slow down intermittently. If the sinus node is functioning properly, sick sinus can be caused by an impulse block near the sinus node slowing, disrupting, or completely blocking conduction. sinus tachycardia – a harmless rhythm and a normal increase in heart rate that happens with fever, excitement, and exercise. It does not require treatment, except in rare cases when an underlying problem, such as anemia or hyperthyroidism, should be treated. supraventricular tachycardia (SVT) – a broad term that includes many forms of arrhythmia originating above the ventricles (supraventricular). This type of arrhythmia may also be called paroxysmal supraventricular tachycardia (PSVT). SVTs usually cause a burst of rapid heartbeats that begin and end suddenly and can last from seconds to hours. These often start when the electrical impulse from a premature heartbeat begins to circle repeatedly through an extra pathway. SVT may cause the heart to beat 160 to 200 times a minute. Although generally not lifethreatening in an otherwise normal heart, symptoms from the racing heart may feel quite strong. These arrhythmias are common in young people. CardioNet, Inc. Glossary Page 4 syncope – is temporary loss of consciousness, described as “fainting” or “passing out,” related to insufficient blood flow to the brain. tachycardia – a heart rate of more than 100 beats per minute. telemetry – the science and technology of automatic measurement and transmission of data by wire, radio, or other means from remote sources to receiving stations for recording and analysis. vasodilator drugs – medications, such as nitroglycerin or nesiritide (Natrecor®), which cause blood vessels to expand, thereby increasing blood flow. ventricle – one of the two lower chambers of the heart. ventricular tachycardia (VT) – VT is characterized by a very fast heart rate and is usually seen with other serious heart disease. This condition can interfere with the heart's ability to pump enough blood to the brain and other vital organs. VT usually requires prompt treatment, with medication, radiofrequency ablation, or surgery. People with VT are often protected with an implantable defibrillator. Because VT can lead to ventricular fibrillation (see below), it is considered a serious condition that warrants aggressive monitoring and treatment. ventricular fibrillation (VF) – sudden cardiac arrest or death, is caused by ventricular fibrillation, an electrical circuitry problem. VF accounts for half of all cardiac deaths. Within seconds, an individual loses consciousness and, without immediate emergency treatment, will die within minutes. If treated in time, VT and VF can be converted into normal rhythm with electrical shock. Estimates indicate that more than 70 percent of VF victims die before reaching the hospital. Wolff-Parkinson-White syndrome (WPW) – a type of SVT is known as Wolff-Parkinson-White syndrome (WPW). This arrhythmia is caused by an extra electrical pathway between the atria and the ventricles. This pathway may allow electrical current to pass between the atria and the ventricles without passing through the AV node, leading to short circuits and rapid heartbeats. ### Sources: American Heart Association, (www.americanheart.org) Heart Rhythm Society, (www.hrsonline.org)