Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Evolution of metal ions in biological systems wikipedia , lookup
Amino acid synthesis wikipedia , lookup
Biosynthesis wikipedia , lookup
Pharmacometabolomics wikipedia , lookup
Proteolysis wikipedia , lookup
Metabolic network modelling wikipedia , lookup
Basal metabolic rate wikipedia , lookup
Chemistry 370 Biochemistry: Macromolecules and Metabolism Summer 2010 London, Cambridge, Paris The goal of this course is to understand the fundamentals of biomolecular structure and function. Key metabolic pathways will be studied within the context of energy utilization by organisms. Particular emphasis will be placed on the discoveries that led to our current understanding of modern biochemistry. Given the condensed nature of this summer course, some preparation prior to arrival in London will be necessary. No lab will be offered, so students wishing or needing CHM370L must take it upon return to campus. Instructor: Dr. Rebecca Alexander Office: 108 Salem Hall (758-5568) email: [email protected] Text: The primary required text is “Lehninger Principles of Biochemistry” (Fifth edition) by Nelson & Cox (ISBN: 978-0-7167-7108-1). Also required is “Foundations of Biochemistry“by Jenny Loertscher and Vicky Minderhout (ISBN: 978-1-60263-524-1) for POGIL (Process oriented guided-inquiry learning). Additional required reading is “The Double Helix” by James Watson. The library has several copies, and it is typically available at used bookstores. Attendance/ Academic integrity: Attendance is required at all lectures and group activities. The first absence or late arrival at a group activity will result in a one letter-grade reduction of the course grade. The second absence or late arrival will cause the student to be sent home. All students are responsible for knowing and observing the Wake Forest University honor system. Grading: There will be weekly exams and a cumulative final. In addition to the exams, there will be several group and individual smaller assignments. Assignments must be turned in on the due date; late submissions will not be accepted. A final paper assignment will be due after completion of the international component of the course. Midterm 1 Midterm 2 Midterm 3 The Double Helix Disease paper Final exam (cumulative) Total 100 pts (20%) 100 pts (20%) 100 pts (20%) 15 pts ( 3%) 45 pts ( 9%) 120 pts (24%) 500 points Grades will be assigned on a 10-point scale. I typically provide an opportunity for extra credit points on exams, and am less flexible with final grades. 90-100% = A (90% guarantees an A-, the A cutoff is usually about 93%) 80-89% = B 70-79% = C 60-69% = D Tentative schedule of lectures Topic # of lectures Chapter (Lehninger) Part I: Structure and Catalysis Amino acids and polypeptides Proteins: Experimental manipulation Protein Structure Protein Function 1 1 2 2 3 3 4 5 2 1 2 6 7 8 1 2 13 14 1 1 1 1 1 1 15 16 19 20 17, 21 23 Exam I – Thursday, June 3 Enzymes Carbohydrates Nucleotides and Nucleic Acids Exam II – Thursday, June 10 Part II: Metabolism and Bioenergetics Principles of Bioenergetics Glycolysis and Gluconeogenesis Exam III – Thursday, June 17 Principles of metabolic regulation Citric Acid cycle Oxidative phosphorylation/ photophosphorylation Carbohydrate Biosynthesis Lipid metabolism Integration of metabolism FINAL EXAM (cumulative): Friday June 25