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Transcript
ï· Therefore entero-hepatic recirculation with des methyl diazepam at 9-12 hours may cause resedation Half Life ï· ï· Half life Midazolam 2-4 hours Half life Diazepam 12-24 hours Phases and Half Life Phases and Half Life ï· Elimination half life is the time required for the drug concentration in the blood to half. ï· Redistribution half-life is the time required for the initial peak level in the tissues to half Side effects of Benzodiazepines Respiratory Depression ⢠⢠⢠CNS depression and muscle relaxation Decreased cerebral response to rise in CO2 Synergism with other CNS depressants Mr J Henry 28/11/2015 4
