... benzodiazepines can produce a dangerous level of sedation.
Some benzodiazepines are metabolized and eliminated slowly from the body, causing a build-up. Elderly
persons are particularly sensitive to the effects of high levels of these drugs. Falls and other accidents can
occur due to dizziness and u ...
Risks Associated with Long-Term Benzodiazepine Use
... uncomfortable withdrawal syndrome that
can last for months. Withdrawal symptoms
are possible after only one month of daily use.
In addition to abuse and dependence,
other major risks associated with benzodiazepine use include the following:
• Cognitive impairment. Benzodiazepines cause acute adverse ...
... Benzodiazepines are among the most commonly prescribed depressant medications in the
United States today. More than 15 different types of benzodiazepine medications exist to
treat a wide array of both psychological and physical maladies based on dosage and
implications.1 To be characterized as such, ...
... U.S. and are mainly used to treat
anxiety and insomnia
• Second most frequently abused
• Combination with other CNS
depressants can cause
dangerous drug interactions,
and contribute to death via
... as they are prescribed. If you have health
concerns related to a benzodiazepine
prescription, talk with your doctor. There
are other approaches to treating anxiety and
People who use benzodiazepines can reduce
their risk of harm by not mixing
benzodiazepines with other drugs, especi ...
... which can be administered in a single dose once a day with Tranxene-SD Half Strength in the 11.25 mg tablet.
The dosage may be increased to 7.5 mg two or three times a day (15–22.5 mg/day). Patients whose symptoms
are stabilized with 7.5 mg three times a day may have their medication switched to Tra ...
... • Tolerance & rebound insomnia.
• Alcohol & CNS depressants potentiate
... of anxiety associated with generalized anxiety
Most persons should be treated for a
predetermined, specific, and relatively brief
UKMi Benzodiazepine Dose Equivalents
... craving, between each dose. For people withdrawing from these potent, short-acting drugs it has
been advised that they switch to an equivalent dose of a benzodiazepine with a long half life such
as diazepam (5). Diazepam is available as 2mg tablets which can be halved to give 1mg doses.
This means t ...
The Anxiety Disorders Some Practical Questions & Answers
... • Don’t forget to identify and treat the primary
• Remember to taper slowly when discontinuing these
• Don’t confuse dependence and addiction.1
• Use short-acting drugs in the elderly—if you must
use them at all.
Informed Consent for Chronic Benzodiazepines (doc)
... medication is stopped or lowered too quickly. Withdrawal symptoms include moodiness, aches and pains, sweating,
diarrhea, abdominal pain, and even seizures.
ADDICTION: Addiction is not the same as dependence. While many people become dependent on daily
benzodiazepines, only a small percentage of the ...
Mammy`s Little Helper - How should we deal with anxiety disorders
... the internet. Reasons for the rise in benzodiazepine use are unclear, but the panel cited an
increase in anxiety disorders, inappropriate prescribing, poor access to psychological
treatments, and lack of knowledge among patients regarding the risk of addiction. Significant
health hazards were highli ...
Chapter 14 Sedative
... GABAA receptor has a structure comprised of multiple
subunits( alpha, beta,gamma, etc). Combinations of the three
major subunits appear to be essential for normal physiologic
and pharmacologic function of the macromolecule.
GABA binds to receptor sites on the beta subunits and that
this interaction ...
... Tolerance develops so they are no longer effective for the condition
for which they were prescribed.
Calculating equivalent doses of oral benzodiazepines
... a "mini-withdrawal", sometimes a craving, between each dose. For people withdrawing
from these potent, short-acting drugs it has been advised that they switch to an
equivalent dose of a benzodiazepine with a long half life such as diazepam (5). Diazepam
is available as 2mg tablets which can be halve ...
Sedative Hypnotics and Their Use and Misuse.ppsx
... (Librium) in 1960, these agents replaced
barbiturates as sedative-hypnotics.
• They cause significantly less respiratory
depression and are rarely lethal by themselves
in an overdose.
Benzodiazepines - Dr Anthony (Tony) Mander
... For some people they may be so severe that they produce confusion,
hallucinations and epileptic fits.
Some people experience unpleasant symptoms for several months
If you have been taking a benzodiazepine for more than a few weeks, talk it
over with your doctor – you ...
Effects of long-term benzodiazepine use
The effects of long-term benzodiazepine use include drug dependence as well as the possibility of adverse effects on cognitive function, physical health, and mental health. There are significant risks associated with the long-term use of benzodiazepines. However, not all people experience problems associated with the long-term use of benzodiazepines. There is evidence that reduction or withdrawal from benzodiazepines can lead to a reduction in anxiety symptoms, while other's anxiety or panic respond only to benzodiazepine treatment. There are a number of side-effects associated with addiction to benzodiazepines such as depression and flu-like symptoms, nonetheless occurring in only a small amount of people. Due to these increasing physical and mental symptoms from long-term use of benzodiazepines, slowly withdrawing from benzodiazepines is recommended for many long-term users, while others benefit from lifelong benzodiazepine treatment and develop neither tolerance nor side effects.Some of the symptoms that could possibly occur as a result of long-term use of benzodiazepines include emotional clouding, nausea, headaches, dizziness, irritability, lethargy, sleep problems, memory impairment, personality changes, aggression, depression, social deterioration as well as employment difficulties, while others never have any side effects from long term benzodiazepine use. Like any other chemical or medicine, one should never abruptly stop using this medicine and should wean themself down to a lower dose under doctor supervision until they are completely off the chemical, if desired. While benzodiazepines are highly effective in the short term, adverse effects in some people associated with long-term use including impaired cognitive abilities, memory problems, mood swings, overdoses when combined with other drugs may make the risk-benefit ratio unfavourable, while others experience no ill effects. In addition, benzodiazepines have reinforcing properties in some individuals and thus are considered to be addictive drugs especially in individuals that have a ""drug-seeking"" behavior; in addition, a physical dependence can develop after a few weeks or months of use, which is not a problem as one slowly lowers their dose. Many of these adverse effects of long-term use of benzodiazepines begin to show improvements three to six months after withdrawal.Other concerns about the effects of long-term benzodiazepine use, in some, include dose escalation, benzodiazepine abuse, tolerance and benzodiazepine dependence and benzodiazepine withdrawal problems. Both physiological tolerance and dependence can lead to a worsening of the adverse effects of benzodiazepines. Increased risk of death has been associated with long-term use of benzodiazepines in several studies, however, other studies have not found increased mortality. Due to conflicting findings in studies regarding benzodiazepines and increased risks of death including from cancer, further research in long-term use of benzodiazepines and mortality risk has been recommended. Most of the research has been conducted in prescribed users of benzodiazepines; even less is known about the mortality risk of illicit benzodiazepine users. The long-term use of benzodiazepines is controversial and has generated significant controversy within the medical profession. Views on the nature and severity of problems with long-term use of benzodiazepines differ from expert to expert and even from country to country; some experts even question whether there is any problem with the long-term use of benzodiazepines. Political controversy, in particular in the UK, also surrounds the long-term use of benzodiazepines, and was subject to the largest class-action lawsuit in the 1980s and 1990s. There have also been allegations of a cover-up by medical bureaucracies and the government.