Download Boost Your Mood Class Recording - Philadelphia Integrative Medicine

Integrative Approach to Mood:
Root Cause Testing to Address
Anxiety, Depression & Mental Health
Philadelphia Integrative Medicine
Georgia Tetlow, MD, ABOIM
Lauren Houser, MS, MSN, CRNP
Rachel Hershberger, MS, CNS, LDN
Marta
• Third antidepressant, what can I try?
• Root cause, personalized approach
• Deficient in EPA?
– Test fatty acids or supplement
• Post partum depression
– Decreased serum zinc
• Integrative Testing
• Sublette et al. Meta-analysis of the effects of eicosapentaenoic
acid (EPA) in clinical trials in depression. J Clin Psychiatry.
2011;72(12):1577-84.
• Mozaffari-Khosravi et al. Eicosapentaenoic acid versus
docosahexaenoic acid in mild-to-moderate depression: a
randomized, double-blind, placebo-controlled trial. Eur
Neuropsychopharmacol. 2013;23(7):636-44.
• Carney et al. Baseline blood levels of omega-3 and depression
remission: a secondary analysis of data from a placebocontrolled trial of omega-3 supplements. J Clin Psychiatry.
2016;77(2):e138–43.
• Roomruangwong et al. Lower serum zinc and higher CRP
strongly predict prenatal depression and physio-somatic
symptoms, which all together predict postnatal depressive
symptoms. Mol Neurobiol. 2016 Feb 5.
Outline
• Gut - Brain connection
• Importance of not suppressing emotion
• Cultural, Social and Developmental
Factors
• Causes: genetics, biology—
neurotransmitters
• Integrative Testing
Gut Brain Connection
• Importance of not suppressing
emotions
– significant physiological consequences
Gut Brain Connection
Background: Mental Disorders
• 26% of Americans 18 and older
experience a diagnosable mental disorder
annually
– Anxiety disorders
– Mood disorders
• Depression
• Bipolar
• Dysthymia
– Impulse Control disorder
– Substance Abuse disorder
Cultural, social and developmental
factors
• Social connection
– social relationships seem to protect individuals
against many physical and psychological disorders
• people can learn a lot by observing what happens to
someone else in a given situation (modeling or observational
learning)
Integrative:
Multidimensional causes
• Factors contributing to our psychology
– Biological
• Genetics, brain and neural systems
– Psychological
• Behavioral and cognitive factors, unconscious
processes, learned helplessness
– Social
• Friends and family, social learning
– Developmental
• More or less reactivity, critical period
Genetic Contributions to Mood
• Genetic
– Genes are very long molecules of DNA at
various locations on chromosomes (23 pairs),
within the cell nucleus
– Most behavior and personality is influenced
by many genes
– There are no individual genes for mental
disorders
– In general – our psychological make-up is
heritable up to 50%
Biological Contributions:
Neurotransmitters
– Chemicals released from one nerve cell to another
– There are multiple neurotransmitter currents (brain
circuits) in the brain
– Drugs can increase/decrease neurotransmitters or
create the opposite effects of a neurotransmitter
Biological Contributions to
Psychopathology I
• Neurotransmitters
– Serotonin
• regulates moods, thought processes, regulation
of eating, sexual and aggressive behavior
• Redux (anti-appetite) & Prozac (antidepressant)
– Gamma Aminobutyric Acid (GABA)
• Reduces anxiety, overall arousal and emotional
responses (aggressive behavior, hostility)
Redux and Prozac affecting
serotonin in synapse
Biological Contributions to
Psychopathology II
• Neurotransmitters
– Norepinephrine
• Controls heart rate, blood pressure, and
respiration; contributes to panic attacks, anxiety
and mood disorders (beta-blockers)
– Dopamine
• Activates other neurotransmitters and aids in
exploratory and pleasure-seeking behaviors
• Excess is implicated in schizophrenia and deficit in
Parkinson’s disease
Summary
• Root cause, personalized approach
• Gut brain connection
– Importance of not suppressing emotion
• Cultural, Social and Developmental
Factors
• Causes: genetics, biology—
neurotransmitters
• Integrative Testing
Thank you
(888) 702-7974 x 0
[email protected]