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Patch Clamp Technique
Patch Clamp Technique is a laboratory technique in electrophysiology that
allows the study of single or multiple ion channels in cells. This discovery
made it possible to record the currents of single ion channels for the first
time, proving their involvement in fundamental cell processes such as
action potential conduction. Erwin Neher and Bert Sakmann developed the
patch clamp in the late 1970s and early 1980s.They received the Nobel
Prize in Physiology and Medicine in 1991 for this work. Patch Clamp
technique can be applied to a wide variety of cells, but is especially useful in
the study of excitable cells such as neurons, cardiomyocytes, muscle fibers
and pancreatic beta cells. It can also be applied to the study of bacterial ion
channels in specially prepared giant spheroplasts.