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Research Paper: Reversal of the P53 Gene From Oncogenic to a Normal Functioning
Student: Nathan Follis
Degree: Master of Arts
College: Sciences and Humanities
Date: December 2015
Pages: 23
This paper will examine P53, a gene that can be mutated into an oncogenic form that can
cause extensive cellular damage. Such mutations can induce a loss of cell cycle control and
promote abnormal cellular growth resulting in tumor formation. The feasibility of mutating P53
back into its original non-oncogenic form will be examined and discussed. Thus, by mutating the
oncogenic P53 gene, it could allow the cell to regain cell cycle control and inhibit further
cancerous growth. Genes P16 and P21 will also be included in the discussion because of their
immense implication in aberrant growth control. P53, if mutated from the cancerous form into
the original form, could reverse multiple types of cancer and activate various tumor suppressor
genes that have altered function due to a P53 mutation.