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VACCINE
Group V
Eka Putri Dewi
(115090107111010)
Ferlany Hardiyanti
(115090101111009)
Nanda Yuli Rahmawati (115090100111010)
VACCINE
A vaccine is substance used to stimulate a
person’s immunity (protection against) a
certain disease.
Some vaccines stimulate immunity by
encouraging the body to make antibodies
(humoral immunity).
KIND OF VACCINE
Live
attentuanted
Inactivated
•Form of the wild virus or bacterium
•Can replicate themselves so the immune
response almost similar to natural infection
•Cannot replicate and thus generally not as
effective as live vaccines
•Immune response mostly antibody based
How to make vaccine?
Fig 1. Mechanism to make vaccine
VIDEO
CHECK THIS OUT
Even 2,500 Years Ago,
People Knew Immunity Worked.
 Greek physicians noticed that people
who survived smallpox never got it
again.
 The insight: Becoming infected by
certain diseases gives immunity.
Fast forward 2300 years
Vaccination
• Edward
Jenner 1796 :
Cowpox/Swinepox
• 1800’s Compulsory childhood
vaccination
Variolation was a huge advance
Smallpox
•1% v. 25% mortality
•Increase immunity
• UK: 1700’s
• China 1950
•Pakistan/Afghanistan/Ethio
pia 1970
pathmicro.med.sc.edu/ppt-vir/vaccine.ppt
As a result, after a world-wide effort
Smallpox was eliminated as a human disease in 1979
Smallpox
pathmicro.med.sc.edu/ppt-vir/vaccine.ppt
How does vaccination work?
Expose the patient to an Antigen
 A live or inactivated substance derived from a
pathogen (e.g bacteria or virus)capable of
producing an immune response
If the patient is subsequently exposed to
infectious agent carrying this Antigen they
will mount a faster immune response
It works like this
Patient exposed to pathogen
Carrying antigens A and B
Molecular Biology of the Cell Alberts et al
How the Vaccine Work ?
Check This Out Our Video
What Is Colustrum ?
Breasts
produce
colostrum
beginning during pregnancy and
continuing through the early days of
breastfeeding.
This special milk is yellow to orange
in color and thick and sticky. It is low
in fat, and high in carbohydrates,
protein, and antibodies to keep the
baby healthy.
Colostrum actually works as a natural and
100% safe vaccine.
It contains large quantities of an antibody
called secretory immunoglobulin A (IgA)
which is a new substance to the newborn.
Before the baby was born, he received the
benefit of another antibody, called IgG,
through placenta
Colostrum vs Breast Milk
Genetically Modified Vaccine
Application Of Genetic Engineering In Development
Using Bacterial Vaccine Hepatitis Saccharomyces
cereviciae To Prevent Hepatitis B Virus Infection