Download Synthesis of Platinum Group Metal Complexes for

Research Group n. 2
UNIVERSITA’ DEGLI STUDI DI PADOVA
Synthesis of Platinum Group Metal Complexes
for Homogeneous Catalysis and Biological Applications
Synthesis of Hybrid, Fluorinated and Nanocomposite Materials
R. Bertani, M. De Nardi, G. Facchin, R.A. Michelin, M. Mozzon, P. Sgarbossa, A. Tassan, E.
Ugel, F. Simionato
Dipartimento di Ingegneria Industriale, Università di Padova, Via F. Marzolo 9, I-35131 Padova;
E-mail: [email protected]
• Synthesis of of Pt(II) and Pd(II) complexes as Lewis acids, containing new C-, N- and P- based
ligands, to be used in homogeneous catalysis such as epoxidation and isomerization of olefins,
hydration of alkynes, Baeyer-Villiger oxidation of ketones and the catalytic formation of C-C
and/or C-X (X = heteroatom) bonds, in organic and acqueous medium.
• Synthesis and biological activity of Pt(II) and Pd(II)-carbene complexes derived by metalpromoted addition reactions of alcohols, thiols, amines and other protic nucleophiles to
coordinated isocyanides. Investigation of the structure/cytostatic activity relationship of the
resulting complexes either in vitro and in vivo.
• Synthesis and biological activity of Pt(II) complexes derived by metal-promoted addition
reactions of alcohols, thiols, amines and other protic nucleophiles to coordinated organonitriles,
alkyl cyanamides and cyanoguanidine. Investigation of the structure/cytostatic activity
relationship of the resulting complexes either in vitro and in vivo.
• Synthesis and characterisation of new phosphazene materials, either trimers and polymers, bearing
different functional groups able to coordinate metal centers or nucleophilic moieties in order to
prepare supramolecular systems and functionalized metal nanoparticles.
• Synthesis of perfluorinated or partially fluorinated organic and organometallic compounds in
order to prepare supramolecular arrangements. Study of the physical/chemical properties of multiblocks semifluorinated compounds either as small molecules and gas dissolving agents.
• Functionalization of clays to prepare nanocpmposites with advanced properties.
• Functionalization of metal and metal oxide nanoparticles and preparation of nanostructured
innovative composites via melt blending.
• Synthesis of new polymer-based nanostructured membranes containing transition metal
complexes via electrospinning, for the catalytic decomposition of volatile organic compounds.
Keywords: Platinum group metals, Homogeneous catalysis, Inorganic synthesis, Antitumor activity,
Nanocomposites, Fluorinated systems, Phosphazenes, Hybrid materials
1. C. Marzano, S.M. Sbovata, V. Gandin, D. Colavito, E. Del Giudice, R.A. Michelin, A. Venzo,
R. Seraglia, F. Benetollo, M. Schiavon, R. Bertani J. Med. Chem. 53 (2010) 6210-6227.
2. R.A. Michelin, P. Sgarbossa, A. Scarso, G. Strukul Coord. Chem. Rev. 254 (2010) 646 – 660.
3. Michelin R., Sgarbossa P, Sbovata SM, Gandin V, C. Marzano, Bertani R (2011). Chemistry
and Biological Activity of Platinum Amidine Complexes. ChemMedChem, vol. 6; p. 11721183.
4. Amadio E, Bertoldini M, Scrivanti A, Chessa G, Beghetto V, Matteoli U, Bertani R., A.
Dolmella. (2011). Synthesis, crystal structure, solution behavior and catalytic activity of a
palladium (II)-allyl complex containing a 2-pyridyl-1,2,3-triazole bidentate ligand. Inorganica
Chimica Acta. vol. 370, pp. 388-393.
5. Cavarzan A., Scarso A., Sgarbossa P., Strukul G., Reek Joost N. H. (2011). Supramolecular
Control on Chemo- and Regioselectivity via Encapsulation of (NHC)-Au Catalyst within a
Hexameric Self-Assembled Host. Journal of The American Chemical Society. vol. 133, pp.
2848-2851.
SUPPLEMENTARY MATERIAL
Detailed list of the components of the research groups
(permanent staff, included graduated students and postdocs)
Name
Surname
Position *
Affiliation
Roberta
Bertani
PA
University of Padova
Marco
De Nardi
PoD
University of Padova
Giacomo
Facchin
RC
ISTM-CNR, Padova
Rino A.
Michelin
PO
University of Padova
Mirto
Mozzon
PA
University of Padova
Paolo
Sgarbossa
RU
University of Padova
Augusto
Tassan
T
University of Padova
Elisabetta
Ugel
PoD
University of Padova
Fabio
Simionato
PoD
University of Padova
*: PO = full professor; PA = associated professor; RU = university researcher; PhD = graduated
student; PoD = postdoctoral fellows; RC = CNR staff; T = technician
Apparatus
(minimum value 25.000 Euro per item)
Type
LCQ-Duo ESI-MS
Spectrum 100 FT-IR
Lambda 19 UV/VIS/NIR
AC-200 NMR
HRGC/MS
TG-DSC
Producer
Finnigan Thermo
Perkin Elmer
Perkin Elmer
Bruker
Carlo Erba
TA Instruments
Year of acquisition
2009
2007
2007
2001
2002
2001
Technical skills
•
•
•
Design and synthesis of functional P-, C- and N- ligands;
Design and synthesis of platinum(II) and palladium(II) complexes for catalytic and biological
applications;
Synthesis of new inorganic or hybrid materials.