Download Caffeic acid in lowering blood glucose in the application

Caffeic acid in lowering blood glucose in the application
Caffeic acid, alias 3,4 - dihydroxybenzoic acid, the structure contains two
hydroxyl groups, is a natural, safe and free radical quencher, has excellent antioxidant
properties. Pharmacological studies have shown that caffeic acid with the blood
circulation, antitussive, expectorant, anti-oxidation, anti-tumor effect, in addition to
treatment for hypertension and cancer than based on specific chemical structure of
caffeic acid and its efficient antioxidant, has been studied in clinical expert in the
treatment of diabetes.
Studies have shown that caffeic acid can correct diabetes in vivo lipid peroxidation
and free radical load. According to the Chinese Clinical Rehabilitation progress report
on research: applications to normal mice fed caffeic acid, showing the increase of
postprandial blood glucose has good inhibition in the experimental group lower
postprandial blood glucose than the control group 23% -55%. Caffeic acid in diabetic
rat renal medulla by stimulating the secretion of B endorphin-like substance into the
sky hypoglycemic effect, as in normal mice was not observed hypoglycemic effect
that this role with non-insulin-dependent. However, this experiment was observed in
normal mice to suppress postprandial hyperglycemia caffeic acid results. Glucosidase
inhibitors competitively inhibit the enzyme activity, so carbohydrate hydrolysis
slowed to avoid a sharp rise in postprandial blood glucose, insulin secretion and thus
slow down, to improve the excessive insulin response, is the type of hypoglycemic
Baitang Ping drugs. Caffeic acid in vitro experiments on the inhibition of glucosidase
Baitang Ping considerable strength and the body of oral glucose tolerance test showed
that caffeic acid significantly inhibited after the polysaccharides such as starch,
disaccharides such as sucrose and the monosaccharides glucose-induced
hyperglycemia, in addition to the application caffeic acid can inhibit glucosidase
activity to explain, but there may be other ways to improve glucose metabolism
pathway, such as the promotion of insulin secretion, and promote the use of fat cells,
glucose uptake, the specific mechanism needs further study. In short, caffeic acid can
reduce the consumption of carbohydrate-induced postprandial hyperglycemia in
normal mice, and glucosidase activity has a strong inhibitory effect, thus lowering
blood sugar.