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Transcript
Caffeic acid in lowering blood glucose in the application Caffeic acid, alias 3,4 - dihydroxybenzoic acid, the structure contains two hydroxyl groups, is a natural, safe and free radical quencher, has excellent antioxidant properties. Pharmacological studies have shown that caffeic acid with the blood circulation, antitussive, expectorant, anti-oxidation, anti-tumor effect, in addition to treatment for hypertension and cancer than based on specific chemical structure of caffeic acid and its efficient antioxidant, has been studied in clinical expert in the treatment of diabetes. Studies have shown that caffeic acid can correct diabetes in vivo lipid peroxidation and free radical load. According to the Chinese Clinical Rehabilitation progress report on research: applications to normal mice fed caffeic acid, showing the increase of postprandial blood glucose has good inhibition in the experimental group lower postprandial blood glucose than the control group 23% -55%. Caffeic acid in diabetic rat renal medulla by stimulating the secretion of B endorphin-like substance into the sky hypoglycemic effect, as in normal mice was not observed hypoglycemic effect that this role with non-insulin-dependent. However, this experiment was observed in normal mice to suppress postprandial hyperglycemia caffeic acid results. Glucosidase inhibitors competitively inhibit the enzyme activity, so carbohydrate hydrolysis slowed to avoid a sharp rise in postprandial blood glucose, insulin secretion and thus slow down, to improve the excessive insulin response, is the type of hypoglycemic Baitang Ping drugs. Caffeic acid in vitro experiments on the inhibition of glucosidase Baitang Ping considerable strength and the body of oral glucose tolerance test showed that caffeic acid significantly inhibited after the polysaccharides such as starch, disaccharides such as sucrose and the monosaccharides glucose-induced hyperglycemia, in addition to the application caffeic acid can inhibit glucosidase activity to explain, but there may be other ways to improve glucose metabolism pathway, such as the promotion of insulin secretion, and promote the use of fat cells, glucose uptake, the specific mechanism needs further study. In short, caffeic acid can reduce the consumption of carbohydrate-induced postprandial hyperglycemia in normal mice, and glucosidase activity has a strong inhibitory effect, thus lowering blood sugar.