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Evidence for reduced glucose transport in Alzheimer's disease. (A) Levels of glucose uptake into different brain regions of the patients with Alzheimer's
disease and age-matched control subjects were quantified by dynamic positron emission tomography using [18 F]-fluorodeoxyglucose. Values are the rate
constant K1 expressed in mL/g/min and reflect glucose transport across the blood–brain barrier and into brain cells. *p ≤ 0.05 compared to corresponding
value for control subjects. (B) Cultured embryonic rat hippocampal neurons, or cortical synaptosomes from adult rats, were pretreated with vehicle or the
antioxidant propyl gallate (PG), and were then exposed for 2 hours to saline (control) or Aβ. Glucose transport was quantified. Note that Aβ caused a
decrease in glucose transport, and that PG blocked the effect of Aβ. (Part A data from Jagust et al. J Cereb Blood Flow Metab. 1991;11:323. Part B data
Source: Chapter 61. Cellular and Neurochemical Aspects of the Aging Human Brain, Hazzard's Geriatric Medicine and Gerontology, 6e
from Mark et al. J Neurosci. 1997;17:1046, and Keller et al. J Neurochem. 1997;69:273.)
Citation: Halter JB, Ouslander JG, Tinetti ME, Studenski S, High KP, Asthana S. Hazzard's Geriatric Medicine and Gerontology, 6e; 2009
Available at: http://mhmedical.com/ Accessed: May 05, 2017
Copyright © 2017 McGraw-Hill Education. All rights reserved