Download Med Chem II - 4-30

Med ChemTutoring for
Anticoagulants,
Antiplatelets, and
Thrombolytics
By Alaina Darby
Anticoagulants
Which of the following is not an
anticoagulant?
A. Dabigatran
B. Warfarin
C. Aspirin
D. Heparin
Which of the following is true of
heparin?
A. Strong base
B. Weak base
C. Weak acid
D. Strong acid
Which of the following makes
heparin acidic?
A. Sulfate groups
B. Alcohol groups
C. Amide groups
D. Peptide bonds
Which of the following is not
involved in the intrinsic pathway?
A. XII
B. XI
C. VII
D. II
Which of the following does not
have a role in both the intrinsic
and extrinsic pathways?
A. I
B. II
C. VII
D. X
Which of the following is
activated by heparin?
A. Thrombin
B. Antithrombin III
C. Prothrombin
D. Fibrin
Which of the following is not true
of heparin?
A. Is used after MI
B. Orally effective
C. Short DOA
D. Causes HIT
Which of the following is a risk
factor for developing a DVT?
A. Phlebitis
B. Pulmonary embolism
C. Lower extremity surgery
D. Myocardial infarction
What is the primary mechanism by
which protamine sulfate works?
A. Binds to ATIII
B. Has coagulant activity
C. Has anticoagulant activity
D. Strongly basic peptide
Which of the following is not an
advantage of LMWH over
heparin?
A. Longer half life
B. Less thrombocytopenia
C. Higher bioavailability
D. Can be given orally
Which of the following selectively
inhibits Factor Xa but has no
effect on thrombin?
A. Fondaparinux
B. Enoxaparin
C. Dalteparin
D. Tinzaparin
Which of the following is a
polypeptide?
A. Heparin
B. Enoxaparin
C. Fondaparinux
D. Desirudin
Which amino acid sequence binds
the thrombin active site?
A. D-Phe-Pro-Arg-Pro
B. D-Pro-Phe-Arg-Pro
C. D-Pro-Arg-Pro-Phe
D. D-Pro-Arg-Phe-Pro
Which of the following can be
used for a patient that has had
HIT?
A. Heparin
B. Argatroban
C. Enoxaparin
D. Fondaparinux
Which of the following is a
zwitterion?
A. Argatroban
B. Dabigatran
C. Rivaroxaban
D. Epixaban
Which of the following is a double
prodrug?
A. Argatroban
B. Dabigatran
C. Rivaroxaban
D. Epixaban
Which of the following is warfarin?
A.
B.
C.
D.
Which of the following is true of the
properties of warfarin?
A. Weak acid; (S) isomer is most active
B. Weak acid; (R) isomer is most active
C. Weak base; (S) isomer is most active
D. Weak base; (R) isomer is most active
Which of the following should be
done for major warfarin overdoses?
A. Drug withdrawal
B. Give vitamin K
C. Give Menadione sodium bisulfite
D. B&C
E. All of the above
Which of the following enhances
warfarin activity?
A. Vitamin K
B. Griseofulvin
C. Metronidazole
D. Phenobarbital
Which of the following enhancers of
warfarin effects is not properly paired
to its mechanism?
A. Phenylbutazole: inhibit CYPs
B. Antibiotics: kill microbes in GIT
C. Chloramphenicol: inhibit CYPs
D. Anabolic steroids: unknown
Which of the following can only
maintain blood up to 21 days?
A. Anticoagulant sodium citrate
B. Anticoagulant citrate dextrose
C. Anticoagulant citrate
phosphate dextrose
D. Anticoagulant citrate
phosphate dextrose adenine
Antiplatelets
Which of the following is not included in
phase I platelet aggregation?
A. Platelets adhere to damaged
subendothelial tissues
B. Platelets don’t adhere to
undamaged endothelial tissue
C. Hemostasis is induced
D. Release chemical mediators from
platelets
Which of the following is not true
of dipyridamole?
A. Induces vasodilation
B. Increases levels of cAMP
C. Decreases adenosine
D. Inhibits PDE3
Which of the following should not
be used as sole therapy?
A. Warfarin
B. Enoxaparin
C. Aspirin
D. Dipyridamole
Into which of the following is
prasugrel classified?
A. PDE3 inhibitor
B. COX inhibitor
C. ADP inhibitor
D. Glycoprotein IIb/IIIa receptor
inhibitor
Into which of the following is
dipyridamole classified?
A. PDE3 inhibitor
B. COX inhibitor
C. ADP inhibitor
D. Glycoprotein IIb/IIIa receptor
inhibitor
Into which of the following is
eptifibatide classified?
A. PDE3 inhibitor
B. COX inhibitor
C. ADP inhibitor
D. Glycoprotein IIb/IIIa receptor
inhibitor
Into which of the following is
aspirin classified?
A. PDE3 inhibitor
B. COX inhibitor
C. ADP inhibitor
D. Glycoprotein IIb/IIIa receptor
inhibitor
Which of the following is a
prodrug that must be activated
by CYP2C19?
A. Ticlopidine
B. Clopidogrel
C. Prasugrel
Fibrinolytics
For which of the following are
fibrinolytics not used?
A. Acute MI
B. Deep vein thrombosis
C. Pulmonary embolism
D. Thrombotic stroke
Which of the following is the
most immunogenic?
A. Streptokinase
B. Alteplase
C. Reteplase
D. Tenecteplase
Which of the following has the
highest specificity for fibrin?
A. Streptokinase
B. Alteplase
C. Reteplase
D. Tenecteplase
Which of the following is not
produced using recombinant
DNA technology?
A. Streptokinase
B. Alteplase
C. Reteplase
D. Tenecteplase