The Renal Drug Handbook
... in the care of patients. Each of us needs to be wary of prescribing for renal patients and this handbook provides a highly practical, user-friendly method of ensuring that appropriate prescriptions are given to patients, whether they have normal renal function, renal impairment, transplants or are r ...
... in the care of patients. Each of us needs to be wary of prescribing for renal patients and this handbook provides a highly practical, user-friendly method of ensuring that appropriate prescriptions are given to patients, whether they have normal renal function, renal impairment, transplants or are r ...
MICROMEDEX® Healthcare Series _ Document
... 2) Once weekly dosing of 90 milligrams (mg) enteric-coated capsules was shown to be safe, effective, and well tolerated for the long-term treatment of depression. After responding to 20 mg daily for acute treatment of depression, patients were successfully treated with the once weekly formulation fo ...
... 2) Once weekly dosing of 90 milligrams (mg) enteric-coated capsules was shown to be safe, effective, and well tolerated for the long-term treatment of depression. After responding to 20 mg daily for acute treatment of depression, patients were successfully treated with the once weekly formulation fo ...
MICROMEDEX® Healthcare Series - Law Project for Psychiatric
... 20 mg daily. Paroxetine is usually taken in the morning and may be taken with or without food (Prod Info Paxil(R), 2002e). 2) For the controlled-release tablet, the usual initial dosage is 12.5 milligrams (mg) daily; the dose may be increased in increments of 12.5 mg/day at intervals of 1 week or mo ...
... 20 mg daily. Paroxetine is usually taken in the morning and may be taken with or without food (Prod Info Paxil(R), 2002e). 2) For the controlled-release tablet, the usual initial dosage is 12.5 milligrams (mg) daily; the dose may be increased in increments of 12.5 mg/day at intervals of 1 week or mo ...
XP13512 [()-1-([(α-Isobutanoyloxyethoxy
... There appears to be a subset of patients with limited ability to absorb gabapentin, possibly due to a lower abundance of the transporter in their intestines. This phenomenon may contribute to the high incidence of nonresponders to oral gabapentin therapy reported in clinical trials in epilepsy, post ...
... There appears to be a subset of patients with limited ability to absorb gabapentin, possibly due to a lower abundance of the transporter in their intestines. This phenomenon may contribute to the high incidence of nonresponders to oral gabapentin therapy reported in clinical trials in epilepsy, post ...
Pharmacological and Pharmaceutical Profile of Valsartan: A Review
... beneficial effects are related to inhibition of Angiotensin II by blockade of AT1 receptor. Valsartan is an orally active Angiotensin II receptor type 1 antagonist which causes reduction in blood pressure and is used in treatment of hypertension. It was first developed by Novartis and has a wide mar ...
... beneficial effects are related to inhibition of Angiotensin II by blockade of AT1 receptor. Valsartan is an orally active Angiotensin II receptor type 1 antagonist which causes reduction in blood pressure and is used in treatment of hypertension. It was first developed by Novartis and has a wide mar ...
Australian public assessment report for Dolutegravir (as sodium)
... antiretroviral therapy (ART), INIs block the action of the integrase (IN) viral enzyme required for HIV replication. Two INIs, raltegravir (RAL) and elvitegravir (EVG), have proved effective and have been approved for use in combination with other ART. However, new therapies continue to be required ...
... antiretroviral therapy (ART), INIs block the action of the integrase (IN) viral enzyme required for HIV replication. Two INIs, raltegravir (RAL) and elvitegravir (EVG), have proved effective and have been approved for use in combination with other ART. However, new therapies continue to be required ...
In Vivo Criteria To Differentiate Monoamine Reuptake Inhibitors from
... reference electrode, were set at approximately maximal and halfmaximal for oxidation of 5-HT. These values were checked frequently and were usually about 590 and 530 mV. The detection limit for 5-HT was approximately 300 fg, based on a signal-to-noise ratio of 3:1. Procedures and data analysis. The ...
... reference electrode, were set at approximately maximal and halfmaximal for oxidation of 5-HT. These values were checked frequently and were usually about 590 and 530 mV. The detection limit for 5-HT was approximately 300 fg, based on a signal-to-noise ratio of 3:1. Procedures and data analysis. The ...
PrCIPRO® XL - Bayer Canada
... prevent the development of an irreversible condition (see ADVERSE REACTIONS). Renal Crystalluria related to ciprofloxacin has been reported only rarely in man because human urine is usually acidic. Crystals have been observed in the urine of laboratory animals, usually from alkaline urine. Patients ...
... prevent the development of an irreversible condition (see ADVERSE REACTIONS). Renal Crystalluria related to ciprofloxacin has been reported only rarely in man because human urine is usually acidic. Crystals have been observed in the urine of laboratory animals, usually from alkaline urine. Patients ...
CIPRO XL PRODUCT MONOGRAPH
... prevent the development of an irreversible condition (see ADVERSE REACTIONS). Renal Crystalluria related to ciprofloxacin has been reported only rarely in man because human urine is usually acidic. Crystals have been observed in the urine of laboratory animals, usually from alkaline urine. Patients ...
... prevent the development of an irreversible condition (see ADVERSE REACTIONS). Renal Crystalluria related to ciprofloxacin has been reported only rarely in man because human urine is usually acidic. Crystals have been observed in the urine of laboratory animals, usually from alkaline urine. Patients ...
product monograph
... outweighs the potential risk to the fetus. Women of child-bearing potential taking fluconazole for vaginal candidiasis should consider using adequate contraception. Fluconazole was administered orally to pregnant rabbits during organogenesis in two studies, at 5, 10 and 20 mg/kg and at 5, 25 and 75 ...
... outweighs the potential risk to the fetus. Women of child-bearing potential taking fluconazole for vaginal candidiasis should consider using adequate contraception. Fluconazole was administered orally to pregnant rabbits during organogenesis in two studies, at 5, 10 and 20 mg/kg and at 5, 25 and 75 ...
PrCIPRO® XL
... prevent the development of an irreversible condition (see ADVERSE REACTIONS). Renal Crystalluria related to ciprofloxacin has been reported only rarely in man because human urine is usually acidic. Crystals have been observed in the urine of laboratory animals, usually from alkaline urine. Patients ...
... prevent the development of an irreversible condition (see ADVERSE REACTIONS). Renal Crystalluria related to ciprofloxacin has been reported only rarely in man because human urine is usually acidic. Crystals have been observed in the urine of laboratory animals, usually from alkaline urine. Patients ...
ANTILIPEMICS 2012 - students [Read
... niacin - vitamin B3 (various OTC “nutraceuticals”) HDL-raising properties discovered 1955, proposed mechanism published 2008 ...
... niacin - vitamin B3 (various OTC “nutraceuticals”) HDL-raising properties discovered 1955, proposed mechanism published 2008 ...
Hydrocodone Polistirex and Chlorpheniramine Polistirex Extended
... depression which may result from overdosage or unusual sensitivity to narcotics including hydrocodone. Therefore, an appropriate dose of naloxone hydrochloride should be administered, preferably by the intravenous route, simultaneously with efforts at respiratory resuscitation. Since the duration of ...
... depression which may result from overdosage or unusual sensitivity to narcotics including hydrocodone. Therefore, an appropriate dose of naloxone hydrochloride should be administered, preferably by the intravenous route, simultaneously with efforts at respiratory resuscitation. Since the duration of ...
Ampicillin
... achieved in ascitic, pleural, and joint fluids. It crosses the placenta and small amounts are distributed into breast milk. There is little diffusion into the CSF except when the meninges are inflamed. About 20% is bound to plasma proteins and the plasma half-life is about 1 to 1.5 hours, but this m ...
... achieved in ascitic, pleural, and joint fluids. It crosses the placenta and small amounts are distributed into breast milk. There is little diffusion into the CSF except when the meninges are inflamed. About 20% is bound to plasma proteins and the plasma half-life is about 1 to 1.5 hours, but this m ...
PREZISTA® (darunavir) oral suspension PREZISTA® (darunavir
... symptoms and acute generalized exanthematous pustulosis, have been reported. Discontinue treatment if severe reaction develops. (5.3, 6) • Use with caution in patients with a known sulfonamide allergy. (5.4) • The concomitant use of PREZISTA/ritonavir and certain other drugs may result in known or ...
... symptoms and acute generalized exanthematous pustulosis, have been reported. Discontinue treatment if severe reaction develops. (5.3, 6) • Use with caution in patients with a known sulfonamide allergy. (5.4) • The concomitant use of PREZISTA/ritonavir and certain other drugs may result in known or ...
MICROMEDEX® Healthcare Series OXCARBAZEPINE
... compared to adults (Prod Info TRILEPTAL(R) oral tablets, oral suspension, 2005) a) Partial seizure, monotherapy 1) 4 to 16 year old, initiation of monotherapy, 8-10 mg/kg/day ORALLY divided doses; may increase dose by 5 mg/kg/day every 3 days to the recommended maintenance dose (Prod Info TRILEPTAL( ...
... compared to adults (Prod Info TRILEPTAL(R) oral tablets, oral suspension, 2005) a) Partial seizure, monotherapy 1) 4 to 16 year old, initiation of monotherapy, 8-10 mg/kg/day ORALLY divided doses; may increase dose by 5 mg/kg/day every 3 days to the recommended maintenance dose (Prod Info TRILEPTAL( ...
Clorhidrato de Propranolol. Monografia del farmaco.
... antimigraine effect of propranolol has not been established. Beta-adrenergic receptors have been demonstrated in the pial vessels of the brain. The specific mechanism of propranolol’s antitremor effects has not been established, but beta-2 (noncardiac) receptors may be involved. A central effect is ...
... antimigraine effect of propranolol has not been established. Beta-adrenergic receptors have been demonstrated in the pial vessels of the brain. The specific mechanism of propranolol’s antitremor effects has not been established, but beta-2 (noncardiac) receptors may be involved. A central effect is ...
PRODUCT MONOGRAPH PrMONUROL® Fosfomycin powder, 3g
... MONUROL (fosfomycin tromethamine), a phosphoric acid derivative is the mono-acid salt of fosfomycin with tromethamine. Fosfomycin is bactericidal in urine at therapeutic doses. Its bactericidal action is due to inactivation of the enzyme enolpyruvyl transferase, thereby blocking the condensation of ...
... MONUROL (fosfomycin tromethamine), a phosphoric acid derivative is the mono-acid salt of fosfomycin with tromethamine. Fosfomycin is bactericidal in urine at therapeutic doses. Its bactericidal action is due to inactivation of the enzyme enolpyruvyl transferase, thereby blocking the condensation of ...
BIAXIN® Filmtab® (clarithromycin tablets, USP) BIAXIN
... Clarithromycin activity against 80 MAC isolates from AIDS patients and 211 MAC isolates from non-AIDS patients was evaluated using a microdilution method with Middlebrook 7H9 broth. Results showed an MIC value of ≤ 4.0 µg/mL in 81% and 89% of the AIDS and non-AIDS MAC isolates, respectively. Twelve ...
... Clarithromycin activity against 80 MAC isolates from AIDS patients and 211 MAC isolates from non-AIDS patients was evaluated using a microdilution method with Middlebrook 7H9 broth. Results showed an MIC value of ≤ 4.0 µg/mL in 81% and 89% of the AIDS and non-AIDS MAC isolates, respectively. Twelve ...
Everolimus Novartis tablet ENG SmPC
... Hepatic transplant patients should have their tacrolimus exposure reduced to minimise calcineurinrelated renal toxicity. The tacrolimus dose should be reduced starting approximately 3 weeks after initiating co-administration with Everolimus Novartis, based on targeted tacrolimus blood trough concent ...
... Hepatic transplant patients should have their tacrolimus exposure reduced to minimise calcineurinrelated renal toxicity. The tacrolimus dose should be reduced starting approximately 3 weeks after initiating co-administration with Everolimus Novartis, based on targeted tacrolimus blood trough concent ...
AusPAR: Rifaximin - Therapeutic Goods Administration
... An absolute bioavailability study of rifaximin is not feasible because of the low solubility of the drug substance. Evidence of low systemic absorption of rifaximin is provided by Study RFPK9801. Following administration of a single oral 400 mg dose of radioactive carbon (14C)-labelled rifaximin in ...
... An absolute bioavailability study of rifaximin is not feasible because of the low solubility of the drug substance. Evidence of low systemic absorption of rifaximin is provided by Study RFPK9801. Following administration of a single oral 400 mg dose of radioactive carbon (14C)-labelled rifaximin in ...
Nystatin - E
... In a study by Bereston (1957), nystatin ointment (100,000 U/g, bid) proved effective in the treatment of cutaneous lesions of Candida in infants and children and there were 6 cures, 2 improvements and 3 failures (duration of treatment 1-8 weeks). The efficacy of a topical cream formulation of nystat ...
... In a study by Bereston (1957), nystatin ointment (100,000 U/g, bid) proved effective in the treatment of cutaneous lesions of Candida in infants and children and there were 6 cures, 2 improvements and 3 failures (duration of treatment 1-8 weeks). The efficacy of a topical cream formulation of nystat ...
PACIFIC BUSPIRONE Presentation NEW ZEALAND DATA SHEET
... The mechanism of action of buspirone is unknown. In contrast to the benzodiazepines, and other anxiolytic agents, buspirone does not exert anticonvulsant or muscle relaxant effects. It also lacks the prominent sedative effect that is associated with more typical anxiolytics. In vitro preclinical stu ...
... The mechanism of action of buspirone is unknown. In contrast to the benzodiazepines, and other anxiolytic agents, buspirone does not exert anticonvulsant or muscle relaxant effects. It also lacks the prominent sedative effect that is associated with more typical anxiolytics. In vitro preclinical stu ...
as a PDF
... potent and selective inhibitors against this CYP isoform are indispensible tools. With use of recombinant CYP2J2 enzyme, screening of substrate and inhibitor of this CYP isoform can be performed, because specific substrate can be useful for profiling CYP2J2 inhibition of drug candidates in vitro in ...
... potent and selective inhibitors against this CYP isoform are indispensible tools. With use of recombinant CYP2J2 enzyme, screening of substrate and inhibitor of this CYP isoform can be performed, because specific substrate can be useful for profiling CYP2J2 inhibition of drug candidates in vitro in ...
Ceftolozane (as sulfate) / Tazobactam (as sodium salt)
... Zerbaxa (ceftolozane/tazobactam) is an antibacterial drug product composed of a cephalosporin and a betalactamase inhibitor. Ceftolozane belongs to the cephalosporin class of antimicrobials. Ceftolozane exerts bactericidal activity through binding to important penicillin-binding proteins (PBPs), res ...
... Zerbaxa (ceftolozane/tazobactam) is an antibacterial drug product composed of a cephalosporin and a betalactamase inhibitor. Ceftolozane belongs to the cephalosporin class of antimicrobials. Ceftolozane exerts bactericidal activity through binding to important penicillin-binding proteins (PBPs), res ...
Discovery and development of direct thrombin inhibitors
Direct thrombin inhibitors (DTIs) are a class of anticoagulant drugs that can be used to prevent and treat embolisms and blood clots caused by various diseases. They inhibit thrombin, a serine protease which affects the coagulation cascade in many ways. DTIs have undergone rapid development since the 90's. With technological advances in genetic engineering the production of recombinant hirudin was made possible which opened the door to this new group of drugs. Before the use of DTIs the therapy and prophylaxis for anticoagulation had stayed the same for over 50 years with the use of heparin derivatives and warfarin which have some well known disadvantages. DTIs are still under development, but the research focus has shifted towards factor Xa inhibitors, or even dual thrombin and fXa inhibitors that have a broader mechanism of action by both inhibiting factor IIa (thrombin) and Xa. A recent review of patents and literature on thrombin inhibitors has demonstrated that the development of allosteric and multi-mechanism inhibitors might lead the way to a more safer anticoagulant.