Download Biochemistry 2EE3 Metabolism and Physiological Chemistry 2002

Biochemistry 2EE3 Metabolism and Physiological Chemistry 2002
Course Outline
Instructor: Dr. Boris S. Zhorov (HSC-4H29, ext. 22049; E- mail: [email protected])
Purpose: To provide a brief introduction to proteins, enzymes and gene expression followed by a more
detailed treatment of energy and intermediary metabolism with emphasis on physiological
chemistry
Learning objectives: Understanding principles of structure and function of biological macromolecules,
energy production and utilization by living orga nisms, metabolic pathways, and mechanisms of
integration and regulation of metabolism
Evaluation of student performance will be based on two tests and a final examination. The final
grade will be calculated as follows: first test 30%; second test, 30%, final examination, 40%.
Percentage grade will be converted to a final letter (see Table below)
%
Letter
%
Letter
%
Letter
%
Letter
100-90 A+
79 - 77 B+
69 - 67 C+
59-57
D+
89 - 85 A
76 - 73 B
66 - 63 C
56-53
D
84 - 80 A72 - 70 B60-62
C52-50
DAll percentage grades within 0.5% of the next letter grade will be reviewed
%
49-0
Letter
F
Questions: Students are encouraged to ask questions in the class and during office hours.
Textbook: Fundamentals of Biochemistry. D.Voet, J.G.Voet, and C.W.Pratt. Wiley & Sons Inc. 2001.
The textbook contains Biochemical Interactions, a CD ROM providing animations and
interactive 3D molecular graphics displays.
Lecture notes: http://www.science.mcmaster.ca/biochem
Lecture notes are not a substitute for the textbook
Academic ethics : Students are asked to reread two documents provided on registration, the Senate
Statement on Academic Ethics and the Senate Resolutions on Academic Dishonesty. Students
should be sure that they understand the expectations the University has of its scholars, and the
possible consequences when these expectations are not met.
Schedule of lectures, tests, and class tutorials
Place: BSB-147. Time: 5:30 – 6:20 p.m. on Mondays, Wednesdays, and Thursdays
Textbook Test
Date
Lecture # and topic a
chapters
Biological molecules
Mo Jan 7 1. Origin of life. Cell.
We Jan 9 2. Energy and molecular interactions
Th Jan 10 3. Amino acids
Mo Jan 14 4. Structure and function of proteins
We Jan 16 5. Nucleic acids
1
1, 6
2, 4, 5
6, 7
3
Lecture # and topic a
Date
Th
Mo
We
Th
Mo
We
Th
Mo
We
Th
Mo
We
Th
Mo
We
Th
Mo
We
Th
Mo
We
Th
Mo
We
Th
Mo
We
Th
Mo
We
Th
Mo
We
a
b
Jan
Jan
Jan
Jan
Jan
17
21
23
24
28
Textbook
chapters
6. Gene expression
7. Carbohydrates
8. Lipids and membranes
9. Enzymes
10. Coenzymes
Cell-to-cell communication
Jan 30 11. Neurons and neurotransmitters
Jan 31 12. Hormones and Receptors
Feb 4 13. Ion channels
Feb 6
Feb 7
Metabolism
Feb 11 14. Overview. High-energy compounds
Feb 13 15. Redox reactions
Feb 14 16. Glucose catabolism I
Mid-term recess
3
8
9, 10
11
Feb 25
Feb 27
Feb 28
Mar 4
Mar 6
Mar 7
Mar 11
Mar 13
Mar 14
Mar 18
Mar 20
Mar 21
Mar 25
Mar 27
Mar 28
Apr 1
Apr 3
Apr 4
Apr 8
Apr 10
14
15
16
16
17
17
17
17. Glucose catabolism II
18. Glycogen metabolism
19. Citric acid cycle I
20. Citric acid cycle II
21. Mitochondrion and electron transport
22. Oxidative phosphorylation
23. ATP. Aerobic metabolism implications
24. Lipid metabolism I
25. Lipid metabolism II
26. Lipid metabolism III
27. Amino acid metabolism I
28. Amino acid metabolism II
29. Amino acid metabolism III
30. Nucleotide metabolism I
31. Organ specialization in metabolism
32. Interorgan metabolic pathways
33. Hormonal control of metabolism
Test
b
Sample questions handing out
b
E-mailing queries
b
b
Class tutorial
Test
13
13
14
19
19
19
20
20
20
22
22
21
21
Topics of some lectures may be subject to change.
Material from several chapters of the textbook will be used.
Test returning
Sample questions handing out
E-mailing queries
Class tutorial
Test
Test returning
Sample questions handing out
E-mailing queries
Class tutorial
Final examination