Download Course Outline - University of Manitoba

IMED 7120 Medical Biochemistry
Calendar Description: Biochemistry of carbohydrates, lipids, proteins and nucleic acids
focused on those areas relevant to structure and function of the human body and disease
processes. All students are expected to have completed an introductory biochemistry course. The
course will consist of lectures, tutorials and assigned studies.Credit hours (3)
Instructors:
Dr. Hao Ding
R326 Basic Medical Sciences Building (BMSB)
Phone: 204-480-1300
E-mail: [email protected]
Dr. Mark Nachtigal
R333 BMSB
Phone: 204-789-3708
E-mail: [email protected]
Dr. Barbara Triggs-Raine
335 Basic Medical Sciences Building, Bannatyne Campus
Phone: 204-789-3218
E-mail: [email protected]
Time and Location of Lectures
Tuesday and Thursday 9:00-10:30 Rm. 341 BMSB
Important Dates:
Winter Term
Mid Term Break
Voluntary Withdrawal
Jan 19th –April 21st, 2017
Feb 20-24th, 2017 (Mid-term break, no classes)
March 31, 2017
Office hours/Contact:
Please contact the professor by E-mail to arrange an appointment
All E-mail communications between the students and the instructors must be done using
University of Manitoba E-mail accounts.
Reference Materials:
The students are referred to the following textbook for additional reading on the topics presented
in the context of lectures, tutorials, assigned studies and presentations to enhance and clarify
materials covering in the lectures, as well as for practise examination questions.
Required text:
King, Michael W. Integrative Medical Biochemistry: examination and board review. McGraw
Hill Education; New York, 2014. ISBN 978-0-07-178612-6
There are several copies of the text in our Departmental library.The “kindle” edition is also
available from Amazon.
For more detail than provided in the textbook, please visit the web site:
http://themedicalbiochemistrypage.org/
Evaluation:
Mid-term exam 1:
Mid-term exam 2:
Assignments:
Final exam:
15%
15%
20%
50%
Mid-term exams will be scheduled in-class. If a student does not write a mid-term exam for
reasons outlined in http://umanitoba.ca/faculties/science/undergrad/resources/899.html , the mark for
the missing mid-term will be assigned as below.
Mid-term missed = (% Achieved in completed mid-term + % achieved in final Exam)/200*15
Late assignments will be accepted up to 7 days after the due date with a loss of 10% of the mark
for each day late.
Tentative Course Outline:
Date
Topic
Section 1: Introduction, protein structure, topology and targeting
Jan 19 Intro to course & review of biomolecules
Jan 24 Protein Structure and Function: Hb as an Example.
a. Connective tissue disorders
b. Hemoglobinopathies, including sickle cell anemia
Jan 26 Enzyme kinetics and marker enzymes
Jan 31 Membrane structure and transport
a. Transporter defects
b. Cystinuria
Feb 2
Protein modification and glycoproteins; cystic fibrosis
Feb 7
Vitamins & minerals (class presentations)
Each student will be assigned one vitamin for which they will
have to make a short class presentation. In addition, each
student will prepare a 500 word summary about a nutritional
supplement.
Feb 9
Nucleotide metabolism
Overview of de novo and salvage pathways
Lesch-Nyhan syndrome
SCIDS
Gout
Feb 14 Heme metabolism
Hyperbilirubinemias
Instructor
L
L
T-Raine
T-Raine
AS
L
T-Raine
T-Raine
T
CP
T-Raine
T-Raine
L
T-Raine
L
T-Raine
Feb 16
Porphyrias
Mid-Term Examination 1
Section 2: Energy metabolism
Feb 28 Cellular metabolism of carbohydrate I: glycolysis, TCA and
oxidative phosphorylation, glucose homeostasis,
gluconeogenesis, glycogen synthesis, glycogenolysis
Mar 2
Cellular metabolism of carbohydrate II: pentose phosphate
pathway, metabolism of galactose and fructose
Mar 7
Cellular metabolism of amino acids
Mar 9
Ethanol metabolism
Mar 14 Cellular metabolism of lipids
Mar 16 Integration of metabolism
Mar 21 Amino acid biomolecules
a. Nitric oxide
b. Tyrosine
c. Tryptophan
d. GABA
e. Glutathione
Mar 23 Cancer metabolism
Mar 28 Mid-term examination 2
Section 3: Lipid metabolism, Lipid derived molecules and disease
Mar 30 Fatty acid, triglyceride and phospholipid synthesis
Apr 04 Dysregulated catabolism: diabetes as an example
Apr 06 Cholesterol and Bile acid biosynthesis and metabolism
a. Familial hypercholesterolemia
b. Smith-Lemli-Opitz Syndrome
c. Inborn errors in bile acid synthesis
d. Gallstones
Apr 11 Other lipids: sphingolipids, ceramides, glycosphingolipids,
eicosanoids
a. Farber lipogranulomatosis
b. Neiman-Pick disease
c. Gaucher disease
d. Tay-Sachs disease
Apr 13 Biologically active lipids and receptors (class assignments)
a. Fatty acids and fatty acid-sensing GPCRs
b. GPR120
c. Oleoylethanolamide (OEA)
d. Omege-3 and Omega-6 UFAs
e. Lysophospholipids
f. Lysophosphatidic acid
g. Lysophosphatidylinositol
Apr 18 Steroid biosynthesis and nuclear receptor signalling I
a. Addison disease
E
T-Raine
L
Ding
L
Ding
L
T
L
L
AS
Ding
Ding
Ding
Ding
Ding
L
E
Ding
Ding
L
T
L
Nachtigal
Nachtigal
Nachtigal
L
CA
Nachtigal
L
Nachtigal
b. Cushing syndrome
c. Congenital adrenal hyperplasia
Apr 20 Steroid biosynthesis and nuclear receptor signalling II
L
Nachtigal
a. Hypothyroidism
b. Graves’ Disease
c. Breast and prostate cancer
L-lecture ∙ T-tutorial ∙ AS-assigned study ∙ E-examination ∙ CA- class assignment
Student Responsibilities
•19003 The student should read and understand the University of Manitoba and Faculty of
Graduate Studies policies on academic dishonesty, including the meaning of “plagiarism and
cheating” and “exam personation”.
The student is referred to:
Course Calendar: Section 8-1:Plagiarism and cheating
(http://crscalprod1.cc.umanitoba.ca/Catalog/ViewCatalog.aspx?pageid=viewcatalog&catalogid=
280&chapterid=1&topicgroupid=17166&loaduseredits=False&search=true&keywords=exam%20personation#)
Course Calendar: Section 5.2.9: Exam personations
(http://crscalprod1.cc.umanitoba.ca/~/Catalog/ViewCatalog.aspx?pageid=viewcatalog&catalogid
=220&topicid=836237&topicgroupid=11826&loaduseredits=true)