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IMED 7120 Medical Biochemistry Calendar Description: Biochemistry of carbohydrates, lipids, proteins and nucleic acids focused on those areas relevant to structure and function of the human body and disease processes. All students are expected to have completed an introductory biochemistry course. The course will consist of lectures, tutorials and assigned studies.Credit hours (3) Instructors: Dr. Hao Ding R326 Basic Medical Sciences Building (BMSB) Phone: 204-480-1300 E-mail: [email protected] Dr. Mark Nachtigal R333 BMSB Phone: 204-789-3708 E-mail: [email protected] Dr. Barbara Triggs-Raine 335 Basic Medical Sciences Building, Bannatyne Campus Phone: 204-789-3218 E-mail: [email protected] Time and Location of Lectures Tuesday and Thursday 9:00-10:30 Rm. 341 BMSB Important Dates: Winter Term Mid Term Break Voluntary Withdrawal Jan 19th –April 21st, 2017 Feb 20-24th, 2017 (Mid-term break, no classes) March 31, 2017 Office hours/Contact: Please contact the professor by E-mail to arrange an appointment All E-mail communications between the students and the instructors must be done using University of Manitoba E-mail accounts. Reference Materials: The students are referred to the following textbook for additional reading on the topics presented in the context of lectures, tutorials, assigned studies and presentations to enhance and clarify materials covering in the lectures, as well as for practise examination questions. Required text: King, Michael W. Integrative Medical Biochemistry: examination and board review. McGraw Hill Education; New York, 2014. ISBN 978-0-07-178612-6 There are several copies of the text in our Departmental library.The “kindle” edition is also available from Amazon. For more detail than provided in the textbook, please visit the web site: http://themedicalbiochemistrypage.org/ Evaluation: Mid-term exam 1: Mid-term exam 2: Assignments: Final exam: 15% 15% 20% 50% Mid-term exams will be scheduled in-class. If a student does not write a mid-term exam for reasons outlined in http://umanitoba.ca/faculties/science/undergrad/resources/899.html , the mark for the missing mid-term will be assigned as below. Mid-term missed = (% Achieved in completed mid-term + % achieved in final Exam)/200*15 Late assignments will be accepted up to 7 days after the due date with a loss of 10% of the mark for each day late. Tentative Course Outline: Date Topic Section 1: Introduction, protein structure, topology and targeting Jan 19 Intro to course & review of biomolecules Jan 24 Protein Structure and Function: Hb as an Example. a. Connective tissue disorders b. Hemoglobinopathies, including sickle cell anemia Jan 26 Enzyme kinetics and marker enzymes Jan 31 Membrane structure and transport a. Transporter defects b. Cystinuria Feb 2 Protein modification and glycoproteins; cystic fibrosis Feb 7 Vitamins & minerals (class presentations) Each student will be assigned one vitamin for which they will have to make a short class presentation. In addition, each student will prepare a 500 word summary about a nutritional supplement. Feb 9 Nucleotide metabolism Overview of de novo and salvage pathways Lesch-Nyhan syndrome SCIDS Gout Feb 14 Heme metabolism Hyperbilirubinemias Instructor L L T-Raine T-Raine AS L T-Raine T-Raine T CP T-Raine T-Raine L T-Raine L T-Raine Feb 16 Porphyrias Mid-Term Examination 1 Section 2: Energy metabolism Feb 28 Cellular metabolism of carbohydrate I: glycolysis, TCA and oxidative phosphorylation, glucose homeostasis, gluconeogenesis, glycogen synthesis, glycogenolysis Mar 2 Cellular metabolism of carbohydrate II: pentose phosphate pathway, metabolism of galactose and fructose Mar 7 Cellular metabolism of amino acids Mar 9 Ethanol metabolism Mar 14 Cellular metabolism of lipids Mar 16 Integration of metabolism Mar 21 Amino acid biomolecules a. Nitric oxide b. Tyrosine c. Tryptophan d. GABA e. Glutathione Mar 23 Cancer metabolism Mar 28 Mid-term examination 2 Section 3: Lipid metabolism, Lipid derived molecules and disease Mar 30 Fatty acid, triglyceride and phospholipid synthesis Apr 04 Dysregulated catabolism: diabetes as an example Apr 06 Cholesterol and Bile acid biosynthesis and metabolism a. Familial hypercholesterolemia b. Smith-Lemli-Opitz Syndrome c. Inborn errors in bile acid synthesis d. Gallstones Apr 11 Other lipids: sphingolipids, ceramides, glycosphingolipids, eicosanoids a. Farber lipogranulomatosis b. Neiman-Pick disease c. Gaucher disease d. Tay-Sachs disease Apr 13 Biologically active lipids and receptors (class assignments) a. Fatty acids and fatty acid-sensing GPCRs b. GPR120 c. Oleoylethanolamide (OEA) d. Omege-3 and Omega-6 UFAs e. Lysophospholipids f. Lysophosphatidic acid g. Lysophosphatidylinositol Apr 18 Steroid biosynthesis and nuclear receptor signalling I a. Addison disease E T-Raine L Ding L Ding L T L L AS Ding Ding Ding Ding Ding L E Ding Ding L T L Nachtigal Nachtigal Nachtigal L CA Nachtigal L Nachtigal b. Cushing syndrome c. Congenital adrenal hyperplasia Apr 20 Steroid biosynthesis and nuclear receptor signalling II L Nachtigal a. Hypothyroidism b. Graves’ Disease c. Breast and prostate cancer L-lecture ∙ T-tutorial ∙ AS-assigned study ∙ E-examination ∙ CA- class assignment Student Responsibilities •19003 The student should read and understand the University of Manitoba and Faculty of Graduate Studies policies on academic dishonesty, including the meaning of “plagiarism and cheating” and “exam personation”. The student is referred to: Course Calendar: Section 8-1:Plagiarism and cheating (http://crscalprod1.cc.umanitoba.ca/Catalog/ViewCatalog.aspx?pageid=viewcatalog&catalogid= 280&chapterid=1&topicgroupid=17166&loaduseredits=False&search=true&keywords=exam%20personation#) Course Calendar: Section 5.2.9: Exam personations (http://crscalprod1.cc.umanitoba.ca/~/Catalog/ViewCatalog.aspx?pageid=viewcatalog&catalogid =220&topicid=836237&topicgroupid=11826&loaduseredits=true)