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Transcript
Biochemistry of thyroid hormone synthesis. In the follicular lumen, tyrosine residues within the thyroglobulin matrix are iodinated by iodine (I+; formed by oxidation of I− by thyroid peroxidase). Iodine bonds to carbon 3 or to carbon 5 of the tyrosine residues of thyroglobulin in a process referred to as the organification of iodine. This iodination of specific tyrosines located on thyroglobulin yields monoiodinated tyrosine (MIT) and diiodinated tyrosine (DIT) residues that are enzymatically coupled to form triiodothyronine (T3) or tetraiodothyronine (T4). The coupling of iodinated tyrosine residues, either of 2 diiodotyrosines or of 1 monoiodotyrosine and 1 diiodotyrosine residue, is catalyzed by the enzyme thyroid peroxidase. Source: Chapter 4. Thyroid Gland, Endocrine Physiology, 4e Citation: Molina PE. Endocrine Physiology, 4e; 2013 Available at: http://mhmedical.com/ Accessed: May 11, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved
