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Name: _________________ Date: ________ Class: ________ Cancer Biology http://www.cancerquest.org/images/FLV/fullDocumentary/English/fullDocInt erfaceEng.swf Cancer and Stem Cell Internet Activity 1. The tasks that are performed each day by specialized structures called______________. 3D Medical Animation – What is Cancer? 2. Organs are made up of _______________. 3. All of these cells work together to do _______________________. http://www.youtube.com/watch?v=LEpTTolebqo 1. Cancer is over 100 different diseases. What classifies a disease as being cancer? 4. Briefly describes what happens to form a cancer cell. 2. Genetic material get damaged or changed from environmental factors (smoking, pollution, contaminated water, etc.) and internal factors. How does this effect some cells? Cell Division 5. What “tells” a cell when do undergo mitosis? 6. What do cancer cells do? 3. What do we call a mass of cancer cells? 4. How does cancer spread to other parts of the body? Control of Cell Division: Normal vs. Tumor 1. Give one way that cancer cells are different from normal cells. 5. Cancer is the leading cause of death for people under the age of ______________. Cellular Organelles: The Nucleus 1. What are the smaller structures in all cells of the body? 6. In the United States, what percentage of people die from cancer? 2. Which organelle is vital in cancer? 3. What specific part in the nucleus contains our genetic information? From Chromosome to DNA 1. What are genes? 2. Do all of our cells contain the same genetic information? Apoptosis 1. If a cell becomes mutated or damaged, the cell will first try to repair itself. If this is not possible, then the cell commit cell suicide known as: __________________________________________________ 3. What then makes cells different? 4. All cancers are thought to result from __________________________ that cause some of the genes to _____________________________________ Gene Mutation 1. What are the alterations in a gene called? 2. Give 3 things that can cause this to occur. Oncogenes and Tumor Suppression 1. Compare how cancer cell division is comparable to a car who’s accelerated it continually pinned against the floor. 2. What are the genes that stop cell division? 3. We get one of these genes from each parents. If one of these is damaged, we can still stop uncontrolled cell division that can lead to cancer. But what if you received two damaged genes, one from each of your parents? Drug Resistance 1. Because cancer cells mutate more often, when they divide, they may mutate again. This means that all cancer cells are not the same in one person’s body. Does this increase or decrease cancer’s ability to resist drug treatments like chemotherapy? 2. What happens to the cancer cells would didn’t die after drug treatment? 3. Why won’t a new tumor respond to the same treatment? Stem Cells http://learn.genetics.utah.edu/content/tech/stemcells/scintro/ 1. Are stem cells differentiated? 2. Explain why are/aren’t stem cells considered to be differentiated. 3. What can a stem cell do? Angiogenesis and Metastasis 1. What is the process by which the tumor forces the body to provide it with nutrients called? 2. What % of cancer related deaths are due to cancer spreading to other parts of the body? 3. What is the name of the process of cancer cells spreading to other parts of the body? 4. Describe 2 ways why most cells that metastasize do not survive. 4. Is a fertilized egg differentiated? 4. After the first few cell divisions have occurred, what causes cells to become differentiated? 5. When we were a blastula, our outer cells eventually made up the ____________ and the cell in the middle made up our _________. 6. About 2 weeks after organization, we have 3 cell layers. The cells of the outer layer or ectoderm become: Research the controversy behind stem cell research in order to answer the following questions. Why is stem cell research controversial? (What is the controversy?) The cells of the middle layer or mesoderm become: What are the different types of stem cells? The cells of the inner layer or endoderm become: 7. How many cell types are there in the body? What are some of the sources of stem cells? 8. Do you have stem cells in your body right now? 9. What important role do somatic or adult stem cells play in the body? 10. They are somatic cells, how many chromosomes would they have? 11. How do somatic stem cells differ from embryonic stem cells? 12. Where could you find stem cells in your body? What do these stem cells give rise to? 13. Write a sentence that describes why we need stem cells? Based on your research, do you agree or disagree with stem cell research and why? (This answer should be about a paragraph.)