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Blood Blood is a specialized bodily fluid (technically a tissue) that is composed of a liquid called blood plasma and blood cells suspended within the plasma. The blood cells present in blood are red blood cells (also called RBCs or erythrocytes), white blood cells (including both leukocytes and lymphocytes) and platelets (also called thrombocytes). Plasma is predominantly water containing dissolved proteins, salts and many other substances; and makes up about 55% of blood by volume. Mammals have red blood, which is bright red when oxygenated, due to hemoglobin. Some animals, such as the horseshoe crab use hemocyanin to carry oxygen, instead of hemoglobin. By far the most abundant cells in blood are red blood cells. These contain hemoglobin, an iron-containing protein, which facilitates transportation of oxygen by reversibly binding to this respiratory gas and greatly increasing its solubility in blood. In contrast, carbon dioxide is almost entirely transported extracellularly dissolved in plasma. White blood cells help to resist infections and parasites, and platelets are important in the clotting of blood. Blood is circulated around the body through blood vessels by the pumping action of the heart. Arterial blood carries oxygen from inhaled air to the tissues of the body, and venous blood carries carbon dioxide, a waste product of metabolism produced by cells, from the tissues to the lungs to be exhaled. Blood performs many important functions within the body including: • • • • • • Supply of oxygen to tissues (bound to hemoglobin which is carried in red cells) Supply of nutrients such as glucose, amino acids and fatty acids (dissolved in the blood or bound to plasma proteins) Removal of waste such as carbon dioxide, urea and lactic acid Immunological functions, including circulation of white cells, and detection of foreign material by antibodies Coagulation, which is one part of the body's self-repair mechanism Messenger functions, including the transport of hormones and the signalling of tissue damage • • • Regulation of body pH (the normal pH of blood is in the range of 7.35 - 7.45) Regulation of core body temperature Hydraulic functions Red blood cells are the most common type of blood cell and the vertebrate body's principal means of delivering oxygen from the lungs or gills to body tissues via the blood. Human red blood cells Red blood cells are also known as RBCs, haematids or erythrocytes (from Greek erythros for "red" and kytos for "hollow", with cyte nowadays translated as "cell"). A schistocyte is a red blood cell undergoing fragmentation, or a fragmented part of a red blood cell. White blood cells, or leukocytes, are cells of the immune system defending the body against both infectious disease and foreign materials. Several different and diverse types of leukocytes exist, but they are all produced and derived from a multipotent cell in the bon marrow known as a hematopoietic stem cell. Leukocytes are found throughout the body, including the blood and lymphatic system. Blood types: 0 contains IgM anti-A antibodies and anti-B antibodies against the A and B blood group antigens. A individuals have the A antigen on the surface of their RBCs, and blood serum containing IgM antibodies against the B antigen. B individuals have the B antigen on the surface of their RBCs, and blood serum containing IgM antibodies against the A antigen. AB individuals have both A and B antigens on the surface of their RBCs, and their blood serum does not contain any antibodies against either A or B antigen.