Download SPT.Retreat.2011

Systems, Pathways and Targets Program
Co-Leaders: Dr. John Lowengrub, Dr. Marian Waterman
Rationale
• Cancer is a complex adaptive system with
dynamic regulatory pathways (dev bio, cell
bio, biochem)
• Modeling dynamic interactions is critical for
understanding progression and response to
treatment (systems bio)
• SPT program reflects this multi-disciplinary
approach to cancer
Systems, Pathways and Targets Program Themes
Systems
Organ
Pathway
Target
Baldi
(Blumberg)
Anderson
(Bardwell)
Bardwell
Calof
Arora
(Edinger)
(Calof)
Donovan
Blumberg
(Fruman)
Frank
(Hoang)
Casali
Kaiser
(Komarova)
(Krowleski)
Chan
Komarova
Lander
(Lander)
Cho
(Steele)
Nie
(Lee, E)
Dai
(Thompson)
Thornton
Limoli
Edinger
(Walsh)
Wan
(Lowengrub)
Fan
(Waterman)
(Wodarz)
(Nie)
Fruman
Wodarz
(Zlotnik)
Schilling
Hoang
(Zlotnik)
Steele
Huang, L
(Wan)
Huang, T
(Zhou)
Kaiser
Krolewski
(Lander)
Lee, E
Levin
Lilly
(Nie)
Sandmeyer
Sassone-Corsi
(Schilling)
Thompson
(Want)
Walsh
Warrior
Waterman
Yokomori
Zlotnik
Program Co-Leader: John Lowengrub
•Angiogenesis
•Macrophages
•Fibroblasts
•Immune cells
Systems Modeling
Komarova
Wodarz
Bench to Bedside: Krolewski, Fruehauf, Lilly, Dash
Bang Hoang
cMet
Neuropilin
In Development Highlights
Wnt Signaling in Sarcomas
Bang Hoang, MD
Wnt Signaling and Metastasis
in Osteosarcoma
WIF-1
Frzb
Druggable Wnt Target Genes
c-MET
Neuropilin
NIH K08 CA11600
2011 Kappa Delta Ann Doher Vaughn Award
Career Development Award: 2011 - 2014
Bench to Bedside: Fruman
PP242
INK12
8
Next-Gen mTOR inhibitors
Dr. David Fruman
Cores: TMF, GHTF, OBC, ETR, BSR
Grants: R03-AI085462
CFCCC Seed Funding
Hyundai Foundation (CHOC, Sender)
NCI multi-PI RO1
submit June 2011
Scientific Highlights
Proteomic Tools
Dr. Lan Huang, PhD: Mass Spectrometry
1. New protein tagging strategies: tandem tags, in vivo biotinylation
2. Novel cross-linking chemistries: click-chemistry, novel spacers
3. Rapid Protein Complex Isolation
Proteasome network
Global Ubiquitination, Neddylation Network
RNA/Protein complexes (MS2-BioTRAP) – NCI IMAT R21CA133275
Tsai BP, Wang X, Huang L, Waterman ML.
2011. Mol Cell Proteomics.
“Quantitative Profiling of In Vivo-assembled
RNA-Protein Complexes Using a Novel
Integrated Proteomic Approach”
planned: NCI IMAT R33
Multi-PI RO1
Scientific Highlights
The p53 Team
p53 Rescue : Dr. Peter Kaiser
NCI R01
2010
A Functional Census of p53 Cancer and Suppressor Mutants
KAISER (GFS; PI) and LATHROP (CSB; contact PI)
“All-codon scanning identifies p53 cancer rescue mutations”
Baronio R., Danziger S. A., Hall L.V., Salmon K., Hatfield G. W., Lathrop R. H.*, and Kaiser P.*
Currently: computational screen of >2,000,000 small molecules
small molecule synthesis and test in cells
Scientific Highlights
The p53 Team
Biology
Kaiser Lab, PI (GFS)
Biological Chemistry
Amaro Group
Pharmaceutical Sciences
Mouse Genetics
Chemistry
Chamberlin Lab (CSB)
Pharmaceutical Sciences
Machine Learning
Lathrop Group, PI (CSB)
Computer Science
Molecular Biology
Hatfield Lab
Computational Biology
Research Laboratory
Molecular Dynamics
Lee Lab (CA)
Biological Chemistry
Structural Biology
Cocco Lab (NMR) (CSB)
Luecke Lab (X-ray) (CSB)
Molecular Biology and Biochemistry
Cancer Center - Value Added
NIH/NCI T32 #CA113265
GHTF Core
CFCCC Seed grants