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Introduction of PTD Technology The Structure of Human Skin 1. Epidermis Is the outermost layer of the skin and protective wrap over the body’s surface 2. Dermis Is the layer of skin beneath the epidermis that consists of connective tissue and cushions the body from stress and strain. 3. Subcutis Due to the protective role of dermis and epidermis, absorption of skin care cosmetics is not easy Protein Transduction Technology Intracellular Plasma membrane Extracellular * PTD carrier makes efficient protein deliver into the cell * Transdermal delivery of a biologically active protein: 2001 Nature Biotechnology (Morris Group) * Macromolecules such as Protein, DNA and Peptide are very difficult to transfer into the cells. However, PTD (Protein Transduction Domain) technology enables effective transfer of these macromolecules possible. We developed 1:1 conjugated PTD and Growth factors such as PTD-EGF(Trade name : SP1-EGF) and PTD-FGF1(Trade name : SP1-FGF1). Our’s PTD technology is superior in terms of using native protein and superior permeability. Core Technology Normal Growth factor SP1-Growth Factor PTD PTD PTD PTD PTD PTD 1 PTD + Growth Factor 2 Penetration 3 Efficient Delivery 4 Skin Renewal (EGF, FGF1) Core technology of this product is PTD technology enabled macromolecules transfer through the skin into the dermis which results in the increase of skin elasticity and alleviation of skin winkles (SP1-EGF & SP1-FGF1), and maximize antioxidant effect (SP1SOD) The Fusion Technology of PTD-Growth Factor The world 1st fused PTD - Growth Factor Expression Technology Recombinant fusion protein purification Technology Refolding Technology while keeping protein activity Advanced assay system for physiological activity