Download the use of i NKT cell ligands as vaccine adjuvants Priyanka B

Boosting the immune response: the use of i NKT cell ligands as vaccine
adjuvants
Priyanka B. SUBRAHMANYAM;Tonya J. WEBB ;
Department of Microbiology and Immunology, University of Maryland School of Medicine and the Marlene and Stewart Greenebaum
Cancer Center, Baltimore, Maryland 21201, USA ;
Fig.1 The Role of NKT cell agonists as vaccine adjuvants. NKT cells can bridge innate and adaptive immune responses. NKT cells recognize lipid antigen in the context of
CD1d molecules. Following activation, NKT cells rapidly secrete cytokines i.e., IFN-γ and can directly mediate cytotoxicity. Cytokine production by NKT cells can lead to the
activation of NK cells, macrophages Mac and in combination with CD40CD40L intercitons lead to the maturation of dendritic cells DC. Thus, the co-administration of an NKT
cells agonist,such as alpha galactosylceramide,with a vaccina may be able to enhance the efficacy of the vaccine by angmenting the magntude of humoral and antigenspecific T cell responses.
Frontiers in Biology,2012,7(5),436-444. Doi:10.1007/s11515-012-1194-2