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Remediation Pharmacology Unit Exam Name: _______________________ Score:____/75 1. Which of the following terms best describes a drug that stimulates a receptor for the parsympathomimic system? A. Anti-cholinergic B. Adrenergic C. Anti-adrenergic D. Cholinergic 2. Which of the following enzyme when stimulated is thought to decrease Acetylcholine? a. Adenlycyclase b. Cholinesterase c. Phosphodiesterase d. Mast cells 3. Which of the following best describes the definition of an adrenergic? A. A drug that blocks the receptor site for epinephrine B. A drug that stimulates the receptor site for epinephrine C. A drug that blocks the receptor site for acetylcholine D. A drug that stimulates the receptor site for acetycholine 4. Alpha 1 receptor stimulation can have which of the following effects? a. Mucous gland hypertrophy b. Bronchial smooth muscle relaxation c. Inhibition of histamine release d. Vessel constriction 5. Which of the following drugs is considered a corticoid steroid? A. Aformeterol B. Foradil C. Fluticosone D. Cromolyn Sodium 6. Which of the following enzymes inactivates cAMP? A. phosodiesterase B. Choline C. Cholinesterase D. Acetyl CoA 7. Single isomer Beta 2 agonists include which of the following? a. Serevent b. Levalbuterol c. Terbutaline d. MicroNefrin 8. Which of the following is a use for Theophylline? a. Increase respiratory muscle strength b. Decrease ventilatory drive c. Decreasing viscosity of mucus d. Blockage of musanaric receptors 9. Which of the following drug blocks the response on the muscarinic (M3) receptor site in the bronchial smooth muscle? A. Levabluterol B. Cholinesterase C. Racemic Epi D. Ipatropium Bromide 10. Foradil is a brand name for which of the following Beta Adrenergics? a. Aformeterol b. Terbutaline c. Fluticasone d. Formeterol 11. Which of the following is considered an expectorant? a. Mucomyst b. Sodium Bicarbonate c. Dornase Alfa d. Tilade 12. Which of the following drugs comes in an MDI formula that is breath activated? a. Advair b. Flovent c. Xopenex d. Maxair 13. Cholinergic stimulation causes all of the following EXCEPT: A. Increase heart rate B. Bronchoconstriction C. Increased saliva production D. Increased contractility of skeletal muscle 14. True or False: The autonomic nervous system is under voluntary control. 15. Which of the following is indicated for pseudomonas? a. b. c. d. Nystatin Amphotericin B Isoconazole Tobramycin 16. Which of the following is a common effect of adrenergic stimulation on airway smooth muscle? A. B. C. D. Bronchodilation Bronchoconstriction Decreased mucus production Increased inflammation 17. When stimulated, which of the following receptors cause bronchoconstriction? a. M 3 b. Beta 1 c. M2 d. Alpha 1 18. Which antiinfective is commonly used for the treatment of RSV? a. Ribavirin b. Tobi c. Intal d. Pentamidine 19. Which of the following would be used in the presence of Croup? a. Albuterol b. Xopenex c. Racemic Epinephrine d. Fluticosone 20. Which of the following is an adverse side effect associated with Atrovent: A. Tachycardia B. Dry mouth C. Hyperkalemia D. Skeletal muscle paralysis 21. Which of the following describes the definition for a Trade (or brand) name? a. The name assigned to a chemical by the USAN council when the chemical appears to have therapeutic use and the manufacture wishes to market the drug. b. Proprietary name given by a particular manufacturer. c. The name indicating the drug’s chemical structure d. The name that is used after the trade mark has expired 22. Which of the following are included in a prescription? I. Patient’s name and address II. Patient’s pharmacist name III. Patient’s dianosis IV. Transcription A. B. C. D. I, and III I and IV II, III and IV All of the above 23. Which of the following is considered hypertonic saline? a. 0.9% NaCl b. 9% NaCl c. 0.45% NaCl d. Sterile water 24. Which of the following is not considered an orphan drug? A. Pulmozyme B. Tobi C. Prolastin D. Albuterol 25. A drug with cholinergic effects would NOT result in which of the following? a. Decreased heart rate b. Salivation c. Secretion of mucus d. Increased heart rate 26. Which of the following definitions describe an antagonist? A. A chemical or drug that binds to a receptor and creates an effect on the body B. A chemical or drug that binds to a receptor but does not create an effect on the body; it actually blocks the receptor site C. An abnormal or unexpected reaction to a drug compared with the predicted effect D. Pertains to the whole body, whereas the target for the drug is not local 27. Which of the following is a indication for Mucomyst? a. Acute Bronchitis b. Intrinsic asthma c. Viral pneumonia d. Acetaminophen overdose 28. Which of the following is considered a route of administration? I. Enteral II. Intrainjectable III. Parenteral IV. Inhalation V. Transmembrane A. B. C. D. I, II and V II, III and IV I, III and IV III, IV and V 29. True or False: The pharmacodynamic phase is the time course and disposition of a drug in the body, based on its absorption, distribution, metabolism and elimination. 30. Mechanisms for inducing bronchodilation include drugs that cause the following actions, except: a. Promote the action of phosphodiesterase b. Block the effects of parasympathetic system c. Prevents the release of calcium and myosin d. Stimulate the conversion of ATP to cAMP 31. Which of the following best describes pinocytosis? A. A rapid decrease in response to a drug B. Incorporation of a substance into a cell by a process of membrane engulfment and transport C. Proportion of a drug that reaches the systemic system D. A cell component that combines with a drug to change or enhance the function of a cell 32. Which organ is the primary site for drug metabolism? A. The Lung B. The Liver C. The Kidney D. The Tissues 33. Which of the following is the unit dose of Xopenex? a. 1.25 mg b. 2.5 mg c. 0.63 mg d. 0.31 mg 34. What effect does endogenous epinephrine have in the body during the fight or flight response? A. Bronchoconstriction B. Vessel dilation C. Decreased heart rate D. Bronchodilation 35. A common side effect with the use of Pulmozyme include:: a. Voice alteration b. Osteoporosis c. Thrush d. Bronchoconstriction 36. Which of the following are advantages of aerosol drug delivery? I. Aerosol doses are smaller than systemic doses II. The number of variables affecting dose III. Rapid onset of drug IV. Dose estimation is difficult A. B. C. D. I, II and IV I and III II and IV All of the above 37. Which of the following aerosol particle size is ideal for upper airway deposition? A. 5-10 microns B. Greater than 10 microns C. 0.8 -2 microns D. 3-5 microns 38. What is the typical frequency for the delivery of Spiriva? a. BID b. QD c. TID d. PRN 39. Which of the following explains aerosol deposition by size and velocity? A. Inertial impaction B. Diffusion (Brownian motion) C. Osmosis D. Gravitational settling 40. What is the typical dose for Pulmozyme? a. 0.5 mg b. 2.5 mg c. 1.25 mg d. 0.63 mg 41. Advair is a combination of: a. Albuterol and Foradil b. Budesonide and formoterol c. Serevent and Fluticosone d. Budesonide and Salmeterol 42. Which of the following is NOT a common dose of Advair DPI? a. 150/50 b. 250/50 c. 100/50 d. 500/50 43. Cells that are inhibited and are involved in airway inflammation do Not include: a. Macrophages b. Eosinophils c. Mast Cells d. Epithelial cells 44. Which of the following is a side effect seen with inhaled corticoid steroids? a. Tachycardia b. Hyperglycemia c. Thrush d. Osteoporosis 45. Which of the following steroid can be nebulized? a. Fluticosone b. Asmanex c. Pulmicort d. Aerospan 46. The use of Pulmozyme is indicated for: a. Prophylactic maintenance with CF b. Bronchiectasis c. CF with infection d. Bacterial pneumonia 47. Please list the mode of action of ALBUTEROL, include all steps for full credit: 48. Please list three side effects of systemic steroids: 49. A 56 year old with bilateral expiratory wheezes is admitted in the ER, the patient is short of breath, SpO2 86% on room air, Please list an appropriate treatment action, include a medication and dose: Medication: ____________________________ Other treatment:________________________ 50. A patient with severe persistent asthma arrives to the ER with bilateral wheezes. The patient is awake/alert. Please list an appropriate treatment action, include a medication(s) and dose: Medication: ____________________________ Other treatment:________________________