Download Medicinal Chemistry-1 - Al

Al-Isra University
Faculty of Pharmacy
Medicinal Chemistry-1
Course outlines
First Semester 2012-2013
Lecturer: Dr. Izzeddin M. Alsalahat
E-mail: [email protected]
Topics:
1.
a.
b.
c.
d.
e.
f.
g.
Introduction to Medicinal Chemistry
Physicochemical properties in relation to biological activity
Drugs and drug targets.
Receptor site theory.
Binding and drug- receptor interactions
Chemical bonding and biological activity.
Stereochemical aspects of drug action
Isosterism and bioisosterism
2.
a.
b.
c.
d.
Autonomic Nervous System
Cholinergic agents
Anticholinergic agents
Adrenergic agents
Anti-adrenergic agent
3.
a.
b.
c.
d.
e.
f.
g.
Central Nervous System
General anesthetics
Anxiolytic, sedative and hypnotic agents
Muscle relaxants
Anticonvulsants
Antidepressants
Antipsychotic
Central nervous system stimulants
4.
a.
b.
c.
d.
e.
f.
Cardiovascular System
Cardiotonic agents
Antihypertensive agents
Anti-anginal agents
Anti-arrhythmic agents
Antihyperlipidemic agents
Anticoagulants
5.
Diuretics
6.
Histamine and Antihistaminic Agents.
1
7.
Local Anesthetics
Textbooks:
1- Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical
Chemistry, 12th edition, 2011.
2- An Introduction to Medicinal Chemistry, Graham L. Patrick, 5th edition 2009.
3- Foye’s Principles of Medicinal Chemistry, 6th edition 2008.
Exams and Grade distribution:
1. First exam
25%
2. Second exam
3. Final exam
40%
4. Quizzes, Homework, etc. 10%
25%
2