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Internet Resources, Chapter 2, Water, Acids, Bases, and Buffers
<tabA2.1>Table A2.1 Acids in the Blood of a Healthy Individual
<T2>Acid
Anion
pKa
Major Sources
<T>Strong acid
Sulfuric acid
Sulfate
Completely
Dietary sulfate and S-
(H2SO4)
SO4−2
dissociated
containing amino acids
3.80
CO2 from TCA cycle
3.73
Anaerobic glycolysis
2.39
Glycolysis
Weak acid
Carbonic acid
Bicarbonate
(R-COOH)
(R-COO− )
Lactic acid
Lactate
(R-COOH)
(R-COO− )
Pyruvic acid
Pyruvate
(R-COOH)
(R-COO−)
Citric acid
Citrate
3.13; 4.76;
TCA cycle and diet
(R-3COOH)
(R-3COO−)
6.40
(e.g., citrus fruits)
Acetoacetic acid
Acetoacetate
3.62
Fatty acid oxidation to
(R-COOH)
(R-COO−)
β-Hydroxybutyric acid β-Hydroxybutyrate
(R-COOH)
(R-COO−)
Acetic acid
Acetate
(R-COOH)
(R-COO−)
Dihydrogen phosphate
Monohydrogen
ketone bodies
4.41
Fatty acid oxidation to
ketone bodies
4.76
Ethanol metabolism
6.8
Dietary organic
(H2PO4−)
phosphate (HPO4−2)
Ammonium ion
Ammonia
(NH4+)
(NH3)
phosphates
9.25
Dietary nitrogencontaining
compounds</T>
<TFN>TCA, tricarboxylic acid.