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NURS 2016 Caring for Individuals Experiencing Endocrine Disorders Endocrine glands secrete chemical substances called hormones. The release of hormones from endocrine glands is regulated via a negative feedback system. The major hormone secreting glands are: hypothalamus, pineal, pituitary, thyroid, parathyroid, thymus, adrenal, islets of langerhorn, and ovaries/testes. Thyroid Gland Produces thyroxin (T4), triiodothyronine (T3), and calcitonin. Needs iodine for hormone synthesis (iodide taken up in diet then converted to iodine in the thyroid). Release of thyroid hormones (T3 & T4 is controlled by Thyroid Stimulating Hormone (THS) secreted by the pituitary. T3 & T4 control the rate of cellular metabolism. Calcitonin reduces elevated serum calcium levels by causing serum calcium to be deposited in bone. Laboratory Tests Thyroid Stimulating Hormone (TSH) Normal: 0.6-5.2mu/L Elevated levels indicate hypothyroidism Low levels indicate hyperthyroidism Cretinism: abnormal fetal growth and development due to untreated prenatal hypothyroidism. Goiter: enlarged thyroid gland due to over secretion of thyroid hormones. Commonly seen with iodine deficiency. Hypothyroidism: affects approximately 5x as many women as men. Most common is 30-60 age group. Clinical Manifestations: due to decreased metabolism, which results in a decreased demand for oxygen, which inturn leads to a decrease in circulation. Decreased pulse Decreased temperature Extreme fatigue Hair loss Brittle nails Dry skin Numbness/tingling in fingers Menstrual disturbances Weight gain Skin becomes thick Mask-like face Mental processes subdued Slowed speech Thyroid Replacement therapy: goal is to restore normal metabolic state. Trade name: Eltroxin Generic name: levothyroxine sodium Therapeutic Action Increase the metabolic rate of body tissues thereby increasing oxygen consumption; respiration and heart rate; rate of fat, protein, and carbohydrate metabolism; and growth and maturation. Indications Replacement therapy for hypothyroidism Pituitary TSH suppression Treatment of myxedema coma Contraindications Allergy to active or extraneous constituents of the drug Acute MI, uncomplicated by hypothyroidism Caution with Addison’s and lactation Adverse effects Allergic skin reaction Symptoms of hyperthyroidism Nursing Assessment Consideration Allergies, acute MI, Addison’s disease, lactation. Skin lesions, colour, temperature, texture Muscle tone Orientation, reflexes, Temperature, respirations, pulse Interventions Monitor response carefully, therapeutic effect is not immediate Do not add IV doses to other IV fluids Administer oral drug as single dose in am. Regular thyroid function test Monitor cardiac response List 4 patient teaching opportunities related to Eltroxin 1. 2. 3. 4. Nursing Considerations: for each of the following Nursing Diagnoses ‘stems’ suggest several nursing interventions 1. Alterations in body temperature 2. Ineffective breathing pattern 3. Activity intolerance 4. Alteration in comfort 5. Alteration in thought processes Hyperthyroidism: Grave’s disease. Most often affects women aged 30-50. The primary dysfunction is excess secretion of thyroid hormones. Clinical Manifestations Nervousness, Irritable hyperexcitable Rapid pulse (90-160) Amenorrehea Excess perspiration Flushed skin Increased appetite Decreased weight Palpitations Poor heat tolerance Exopthalmus Fatigability/weakness Management: Goal restore metabolic rate Radioactive iodine treatment: destroy overactive thyroid cells. 70-85% patients cured with one dose high incidence of hypothyroidism patient/family fear of radioactive component Nursing Considerations: On the following table, identify 4 nursing diagnosis that are related to hyperthyroidism and such at least 3 sound nursing interventions to address each. Nursing Diagnosis 1. Interventions a) b) c) d) 2. a) b) c) d) 3. a) b) c) d) 4. a) b) c) d) Thyroid storm (Thyrotoxic Crisis) A form of severe hyperthyroidism. Onset is abrupt and condition is life-threatening. Causes include: physical and emotional stress (injury, infection, surgery), and abrupt withdrawal from antithyroid medications. Manifestations Pyrexia (>38.5) Tachycardia (>130/min) Delirium Exaggerated hyperthyroid Disturbance of major systems symptoms (digestive, CV, neur) Management Oxygen therapy, humidified (to meet demand of high metabolic rate) Monitor oxygen saturation rate (pulse oximetry, arterial blood gas) Medication o Non-ASA antipyretic medication/ therapy o Hydrochorithiazide to treat adrenal insufficiency o Propranolol and digitalis to reduce cardiac symptoms o Agents to impede conversion of T4 to T3 Adrenal Gland: Adrenal cortex Definition Clinical Manifestations Diagnostic findings Management Nursing Considerations Addison’s Disease Insufficient Insufficient corticosteroid and mineralcorticoid production Muscle weakness, fatigue, dark pigmentation of skin, hypotension, GI disturbance, severe wt loss, hypoglycemia, hyponatremia, hyperkalemia. Decreased serum Na and Bl.g Low plasma catecholemines and cortisol Addisonian Crisis: hypotensive crisis. Hydrocortisone Increase BP Fluid replacement Gl and elect. replacement Monitor for Addisonian Crisis Assess stress levels and coping strategies. Risk for fld volume def. Risk for infection Activity intolerance. Health teaching re: possible hormone replacement therapy. Cushing’s Disease Excess Excess corticosteroid and mineralcorticoid production Moon face Central obesity: buffalo hump, pendulous abdomen. Skin: thin, fragile, oily, acne Muscle wasting, osteoporosis Na retention Hyperglycemia Decreased libido Virilization of women Increased Na and Bl.g Decreased K Surgical removal of tumor if cause is pituitary tumor. Adrenalectomy is cause is adrenal tumor Risk for injury Provide high protein, Ca, and vit D diet. Reduce Na and caloric intake. Risk for infection Impaired skin integrity Altered body image/selfesteem