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Transcript

Molecular Basis of Contraction
(Cont.)
Sliding Filament/Cross-Bridge Theory of
Muscle Contraction
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ATP hydrolysis provides the energy for crossbridging and affects affinity of myosin for actin
Myosin has high affinity for actin when ADP and Pi
are bound; low affinity when ATP is bound
Myosin cycles between high- and low-affinity
states, making and breaking cross-bridges with
the actin filament
Elsevier items and derived items Â© 2010, 2005 by Saunders, an imprint of Elsevier Inc.
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