Download Chapter 48 Antidysrhythmic Drugs

Chapter 83
Aminoglycosides:
Bactericidal Inhibitors
of Protein Synthesis
Copyright (c) 2004 Elsevier Inc. All rights reserved.
Aminoglycosides: Bactericidal
Inhibitors of Protein Synthesis
• Can cause serious injury to inner ear
and kidney
• Narrow spectrum antibiotic
• Microbial resistance
• Use: aerobic gram-negative bacilli
• Adverse effects
– Nephrotoxicity
– Ototoxicity
– Hypersensitivity reactions
– Neuromuscular blockade
– Drug interactions
Copyright (c) 2004 Elsevier Inc. All rights reserved.
Gentamicin (Garamycin)
• Serious infections caused by aerobic gram-negative bacilli
• Uses
– Pseudomonas aeruginosa
– Escherichia coli
– Klebsiella
– Serratia
– Proteus mirabilis
• Adverse effects
– Nephrotoxicity
– Ototoxicity
Copyright (c) 2004 Elsevier Inc. All rights reserved.
Other Aminoglycosides
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Tobramycin (Nebcin)
Amikacin (Amikin)
Netilmicin (Netromycin)
Neomycin
Kanamycin (Kantrex)
Streptomycin
Paromomycin (Humatin)
Copyright (c) 2004 Elsevier Inc. All rights reserved.