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SUPPLEMENT C: GROUPING OF INFECTIOUS AGENTS Table 1: Grouping of infectious agents into classes (i.e., bacteria, viruses, fungi, parasites) Species Acanthamoeba polyphaga Adenovirus Aspergillus spp. Bacillus cereus Bovine Kidney virus Blastocystis hominis Blastomyces dermatitidis Bordetella spp. Campylobacter jejuni Candida spp. Chikungunya virus Chlamydia spp. Cytomegalovirus Demodex folliculorum Dengue virus Eikenella corrodens Entamoeba coli Enterobacter spp. Enterococcus faecalis Enterovirus Epstein-Barr Virus Escherichia coli Filarial nematodes Geotrichum candidum Giardia spp. Haemophilus influenzae Helicobacter pylori Hepatitis A-G Virus Herpes Simplex Virus Histoplasma capsulatum Human Herpes Virus Human Immunodeficiency Virus Human Papillomavirus Influenza virus Klebsiella spp. Measles virus Moraxella catarrhalis Mycobacterium spp. Mycoplasma spp. Neisseria gonorrhoeae Orientia tsutsugamushi Parainfluenza virus Penicillium spp. Poliovirus Proprionibacterium acnes Proteus mirabilis Pseudomonas aeruginosa Respiratory Syncytial Virus Rhinovirus Rhizopus nigricans Rickettsia spp. Rotavirus Rubella virus Salmonella spp. Schistosoma spp. Serratia marcescens Staphylococcus spp. Streptococcus spp. Toxocara spp. Toxoplasma gondii Transfusion Transmitted Virus Treponema spp. Trichomonas vaginalis Tropheryma whipplei Trypanosoma cruzi Ureaplasma urealyticum Abbreviation (if applicable) BK virus CMV EBV HAV, HBV, HCV, etc. HSV HHV HIV HPV RSV TTV Class Parasite Virus Fungi Bacterium Virus Parasite Fungus Bacteria Bacterium Fungi Virus Bacteria Virus Parasite Virus Bacterium Parasite Bacterium Bacterium Virus Virus Bacterium Parasites Fungus Parasites Bacterium Bacterium Virus Virus Fungus Virus Virus Virus Virus Bacteria Virus Bacterium Bacteria Bacteria Bacteria Bacterium Virus Fungi Virus Bacterium Bacterium Bacterium Virus Virus Fungus Bacteria Virus Virus Bacteria Parasites Bacterium Bacterium Bacterium Parasites Parasite Virus Bacteria Parasite Bacterium Parasite Bacterium Species Vaccinia virus Varicella Zoster Virus Vibrio cholerae Wuchereria bancrofti Abbreviation (if applicable) VZV Class Virus Virus Bacterium Parasite Note: Viruses act intracellularly and are able to utilise the information system of the host cells and act on the DNA, RNA, or protein level. Interpretation of the results in Figure 8 suggests that viruses are the most versatile agents as they were capable of causing disease in every organ system included in this review. Also, when analysing the chronic conditions most frequently identified in the current review, viruses were most often implicated in the aetiology, followed by bacteria, fungi, and parasites. There were several different bacterial genera identified in this review, and they were capable of causing disease in almost every disease area. Bacteria may generally be associated with organs that are exposed to the “exterior”, such as the respiratory tract. They may inflict damage by secreting enzymes or toxins that interfere with biochemical processes of cells or organ systems (e.g., shiga or cholera toxins and superantigens). There were a limited number of parasites identified in the review, but they were capable of causing disease in many organ systems. Parasites are highly specialised and adapted to their individual host and they can have a number of adverse impacts by replicating in certain organs and tissues, by secreting toxic substances or merely due to their size. There were also a small number of fungal genera identified in this dataset. Fungi are also often associated with organs exposed to the “exterior” surfaces of the body and, in the current data-set; they seemed to have a propensity to be associated with the respiratory tract.