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Improper chromosome alignment on the mitotic spindle can activate the spindle checkpoint mediated by the BUB1, BUB3, BUBR1, and MAD2 proteins
that localize to kinetochores. An intact spindle checkpoint induces metaphase arrest through inhibition of the APC. Defective spindle-checkpoint function
results from either loss of BUB1- and BUB3-dependent signaling or abrogation of MAD2, BUBR1-mediated inhibition of the APC. This leads to the
absence of a functional mitotic spindle checkpoint generating aneuploid cells. (Adapted from Stewart et al, 2003.)
Source: Genomic Stability and DNA Repair, The Basic Science of Oncology, 5e
Citation: Tannock IF, Hill RP, Bristow RG, Harrington L. The Basic Science of Oncology, 5e; 2016 Available at: http://mhmedical.com/
Accessed: August 09, 2017
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