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1st Lecture: Pro-‐ and an>-‐aging genes General part • Aging defini;on • Theories of aging • How can aging be studied • Model organisms to study aging Experimental part on C. elegans • Advantages of C. elegans to study aging • Age-‐associated changes (morphological and physiological) • Lifespan regula;ng pathways (pro and an;-‐aging genes) Take home messages 1. Aging defini;on: a progressive loss of morphological and physiological integrity, leading to impaired func;ons and increased vulnerability to death. 2. Aging driving forces (Gene;c program and Exogenous factors) 3. Model organism are suitable to study aging (conserved responses/ effects between species) 4. C. elegans is a powerful model organism for aging and longevity studies (short life cycle, defined gene;c associated phenotype, conserved pathways and responses etc…) 5. Many of the C. elegans longevity/aging pathways are conserved with higher eukaryotes 6. Aging can be ar;ficially modulated by gene;c and exogenous interven;ons 7. Detailed escrip;on of pro and an; aging genes belonging to different pathways (IGF/insulin, mitos, CR, autophagy, germline)