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NUS Graduate School for Integrative Sciences and Engineering Research Project Write-up Title of Project : Deciphering the links between Cancer and Aging via an integrOmics Network-based Meta-analysis approach (ACMON) Name of Supervisor : Prof. Tassos Bezerianos Contact Details: email: [email protected], tel: 66013054 Short Description The aging of populations worldwide is leading to an unprecedented increase in cancer cases and fatalities. Understanding the links between cancer and aging is therefore more important than ever. Moreover, the reported existence of cross- and tissue-specific tumor markers hampers even more the identification of bridges between the underlying processes. From the drug design perspective, the failure of single-target drugs to treat complex diseases with optimal efficacy shifted the therapy to multi-target drugs. In parallel, the avalanche of network-based integromics approaches allows the generation of systems-biology pipelines serving as subvening tools for biomarker detection. The proposed project aims at setting the hallmarks of the interconnection of cancer and aging from the Systems Biology viewpoint to determine novel prognostic and diagnostic target sets in the form of communities (modules) with higher discriminative power. For this, a network-based integromics meta-analysis pipeline will be designed to combine interaction data along with a large cohort of publicly available expression data from multiple cancerous tissues in mouse model and human for which age-related expression data are also available. The results open new avenues for developing effective therapies against cancer under the aging prism. The output communities will enable the exploration of the ageassociated differences in incidence and progression between cancer sites that probably reflect different processes and risk factors. Unraveling the age-related communities, important for oncogenic development in different tissues, could allow more personalized drug development and improved cancer treatments.