Download Pharmacogenetics

Pharmacogenetics
A Topic Overview
Shannon Staton
PharmD 2016
Video Overview
O Pharmacogenetic Video
O Stop at 2:13
Definitions
O Pharmacogenetics – the study of how
people respond differently to medicines due
to their genetic inheritance
O Pharmacology + Genetics
O The study of how drugs work in the body
O The study of how traits are inherited
O Pharmacogenomics – the study of how
genes affect a person’s response to drugs
Goal
O To be able to predict (from a patient’s
genetic make-up) how well a medicine will
work in his/her body, as well as, to predict
the likelihood of side effects
O Leads to the practice of “personalized
medicine”
O Enough of the right medicine, to the right
person
Controversy
O Exists with genetic profiling
O Profiling of patients raises issues about
confidentiality and ownership of information
O Examples:
O Is telling a patient they are susceptible to
cancer for life helpful? Can we prevent the
cancer?
O Is telling a patient they carry a gene for
Alzheimer’s disease later in life detrimental to
their well-being?
Example: STATINS
O STATINS (moderate or high intensity therapy)
are used for:
O Patients with cardiovascular disease
O Patients with LDL or “bad” cholesterol
O Patients with Type 2 diabetes; between ages
40 to 75 years of age
O Patients with an estimated 10-year risk of
CVD of 7.5% or higher, between ages 40-75
years of age
Use
O If any of those genes used for
pharmacologic pathways in statin therapy
(previous slide) have an SNP (single
nucleotide polymorphism) this will effect the
way the drug affect’s the body, thus
effecting the RESPONSE of statin in lowering
LDL and preventing CVD
O A choice of a different statin or another
class entirely may be considered
O Innovative firm providing affordable genetic
testing without health insurance hurdles
O Simple mouth swab test provided at pharmacies
O Pharmacogenetic testing firm providing genetic
testing for:
O Statins
O Antiplatelets
O ADHD
O Pain
Questions/Discussion?