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Transcript
Comparison of the GLA containing zymogens. The figure shows basic structural elements of the GLA-containing zymogens. Each circle is an amino acid. The prepro leader sequence contains the signal peptide, as well as elements that direct carboxylation of glutamyl residues. Cleavage of the leader sequence is indicated by showing a slight separation from the mature protein. All have a GLA domain with the GLA residues indicated by filled blue circles. Prothrombin has a finger loop followed by two Kringle domains. Factors VII, IX, X, and protein C have epidermal growth factor-like domains. Prothrombin, factor VII, and factor IX circulate as single-chain molecules. Factor X and protein C circulate as two chains that are disulfide linked. All have a catalytic domain that is homologous between the GLA-containing zymogens. The active site His, Asp, and Ser residues are indicated by the black circles in the Source: Chapter 115. Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostasis, Williams Hematology, 8e catalytic domain. Cleavages that convert the zymogen to an active enzyme are indicated by the arrows. In factor IX, factor X, and protein C, the released Citation: Lichtmanby MA, TJ, Seligsohn Kaushansky Prchal JT. Williams Hematology, 8e; 2010 Available at:The http://mhmedical.com/ activation peptide is indicated theKipps yellow circles. AfterU, cleavage, all ofK,the molecules are two-chain disulfide-linked molecules. disulfide connecting Accessed: August 03, 2017 the catalytic domain with the rest of the molecule is shown by the heavy bond. All catalytic domains but that of prothrombin remain attached to the GLA Copyright © 2017 McGraw-Hill Education. All rights reserved domain following activation.