Download Tailoring cell microenvironment cues to guide mesenchymal stem

Department of Mechanical and Biomedical Engineering
Seminar Series
Tailoring cell microenvironment cues to
guide mesenchymal stem cell chondrogenesis
for engineering cartilage tissue
Dr. Liming Bian
Polymeric Biomaterials Laboratory
Department of Bioengineering, University of Pennsylvania, USA
Date:
Time:
Venue:
17 Jan., 2012 (Tuesday)
2:30pm < Tea Reception at 2:15pm >
Room B6619 (SEEM & MBE Conference Room)
ABSTRACT
When endogenous repair fails, as is often the case with musculoskeletal
tissues (like the articular cartilage, knee meniscus, bone, intervertebral
disc etc.), novel strategies and enabling technologies must be developed
to enhance tissue regeneration. Since the late 1990s, tissue engineering
has been developing at a significant pace towards clinically relevant
technology to promote tissue regeneration. Meanwhile, in recent years,
mesenchymal stem cells (MSCs) have been evolving with increasing
popularity as a clinically relevant cell source within the rapidly
expanding field of tissue engineering. Furthermore basic science studies
have shown that the survival, maintenance and differentiation of stem
cells are tightly regulated by mechanical, biochemical, intercellular and
neural signals from their local microenvironment. This seminar talk
focuses on the effects of mechanical and biochemical cues on the
chondrogenic differentiation of MSCs for cartilage repair. Our findings
demonstrate that carefully designed mechanical conditioning regimen
and controlled delivery of chemical factors are crucial to the
development of tissue engineered cartilage using MSCs. These findings
provide important insights into clinical translation of stem cell therapy
for cartilage repair.
ABOUT THE SPEAKER
Dr. Liming Bian has been a postdoctoral researcher working for Dr.
Jason A. Burdick at the Polymeric Biomaterial Laboratory in the
Department of Bioengineering, the University of Pennsylvania since
2009. After receiving his B.Eng and M.Sc degree from the National
University of Singapore in 2002 and 2004, respectively, Dr. Bian
completed his Ph.D. study in Biomedical Engineering under the
advisory of Dr. Clark T. Hung and Dr. Gerard A. Ateshian at Columbia
University in 2009. His research is focused on stem cell tissue
engineering for repairing soft musculoskeletal tissues. Dr. Bian is also
interested in the development of biomaterial platforms to investigate the
role of cell microenvironment factors including mechanical, chemical
and cell-matrix interactions in stem cell differentiation.
Dr. Bian's work has been published in peer-reviewed journals including
Tissue Engineering, the Journal of American Sports Medicine,
Osteoarthritis and Cartilage, the Journal of Biomechanics and
Biomaterials. Dr. Bian is an affiliated member of the Orthopedic
Research Society, American Chemical Society and Society for
Biomaterials. Dr. Bian also served as an active reviewer for Tissue
Engineering, the Journal of Biomedical Materials Research and the
Journal of Biomechanical Engineering.
Enquiry: 3442 8420
All are welcome!
MBE Seminar 2011-2012/017