Download HL Construct your own polypeptide

Structures of Amino Acids
Amino
Acid
Name
R = any number carbons in a hydrocarbon chain
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A
A
b
b
r
r
Structure
e
e
of R group (red)
v.
v.
Comments
Alanine
ala
A
Neutral
Non-polar
Arginine
arg
R
Basic
Polar
Asparagine
asn
N
Neutral
Polar
Aspartic
Acid
asp
D
Acidic
Polar
Cysteine
cys
C
Neutral
Slightly
Polar
Glutamic
Acid
glu
E
Acidic
Polar
Glutamine
gln
Q
Neutral
Polar
Glycine
gly
G
Neutral
Non-polar
Histidine
his
H
Basic
Polar
Isoleucine
ile
I
Neutral
Non-polar
Leucine
leu
L
Neutral
Non-polar
Lysine
lys
K
Basic
Polar
Methionine
met
M
Neutral
Non-polar
Phenyl-alanine
phe
F
Neutral
Non-polar
Proline
pro
P
Neutral
Non-polar
Serine
ser
S
Neutral
Polar
Threonine
thr
T
Neutral
Polar
Tryptophan
trp
W
Neutral
Slightly
polar
Tyrosine
tyr
Y
Neutral
Polar
Valine
Val
V
Neutral
Non-polar
Building and Folding a protein!
Today you have been given a challenging task.
Can you construct a polypeptide and fold it into a quaternary structure?
You will be given a fictional ‘protein’ to construct that is 10 amino acids in length
You will need to show all 4 stages of folding (primary, secondary both beta sheet and alpha
helix) on your poster including any bonds that can form between the amino acids
You will need to use the data sheet to help you, pay particular attention to the amino acids
chemical structure and properties to help you identify which bonds may form
Important! Remember that if your amino acid has acidic properties then it has a relatively
negative charge, if your amino acid has basic properties then it has a relatively positive
charge
Polypeptide to construct: Cysteine, Glycine, Alanine, Methionine, Aspartic Acid, Glycine,
Arginine, Lysine, Serine, Alanine
Good Luck!
Extension
If you complete the above task then you can add a list of globular and fibrous proteins to
your poster and briefly describe the difference in function between the two.