Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Gel electrophoresis of nucleic acids wikipedia , lookup
Non-coding DNA wikipedia , lookup
Community fingerprinting wikipedia , lookup
Molecular cloning wikipedia , lookup
Nucleic acid analogue wikipedia , lookup
DNA vaccination wikipedia , lookup
Transformation (genetics) wikipedia , lookup
Afamelanotide wikipedia , lookup
DNA supercoil wikipedia , lookup
Artificial gene synthesis wikipedia , lookup
Exposure to UV light Thymine dimer No replicating DNA strand Nucleotide excision repair Recognization Unwinding Cleavage Filling Sealing NUCLEOTIDE EXCISION REPAIR skin • Uvr-ABC excinuclease • DNA Polymerase • DNA Ligase GENE UV SKIN The POL H gene (encoded DNA polymerase eta (Pol η)) protecting cells from UV thatinduced DNA damage Xeroderma pigmentosum fix DNA damage Type A, I, XPA Type E, V, XPE Type B, II, XPB Type F, VI, XPF Type C, III, XPC Type G, VII, XPG Type D, IV, XPD Type V, XPV Signs and Symptoms of Xeroderma Pigmentosum Severe sunburn when exposed to small amounts of sunlight. These often occur during a child's first exposure to sunlight. Development of many freckles at an early age Skin Cancer Eyes that are painfully sensitive to the sun and may easily become irritated and bloodshot Blistering exposure on minimum sun Spidery blood vessels Scaly and dry skin Irregular dark spots on the skin Bloodshot freckles blister blister Scaly skin DIAGNOSIS Usually detected in early infancy 1-2 years Clue to diagnosis - severe sunburn after first exposure to the sunlight The diagnosis of XP is made on the basis of clinical findings and family history The diagnosis of XP is based on skin, eye, and nervous system XP can be diagnosed by measuring the DNA repair factor from skin or blood sample Treatment For XP Protection from UV Eye and skin exam Prompt removal of cancerous tissue Neurological exam Psychososial care PrOGNOsi$ *Many patients die at an early age from skin cancers.but,if a person is diagnosed early, does not have severe neurological symptoms and takes all the precautionary measures to avoid exposure to UV light, they may survive beyond middle age. < 40% of individuals with the disease survive beyond age 20. Some with less severe cases manage to live well into their 40s