Download Izzeddin M - Al-Isra University

Izzeddin M. M. Alsalahat
Personal Information
Address:
Nationality:
E-mail:
26 B Mohammad Hamzeh Street, Al Jubayhah, Amman
Jordanian/British
[email protected]
Aims
Looking to maximize my potential, equip my self with more knowledge and apply my skills
towards becoming an established researcher, bringing to light new solutions to difficult problems.
I am a self-starter and a motivated individual with aspirations of academic distinction and career
success. My ultimate aim is to excel in my research to the point where the research I conduct is
fundamental to the wellbeing of mankind.
Qualifications & Achievements
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PhD in Pharmacy and Pharmaceutical Sciences– Medicinal Chemistry
University of Manchester, UK
2012
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Bachelors of Pharmacy (1st Class degree with honours)
Al-Isra University, Jordan
2004
General Secondary Certificate
Jordan
1997
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Hands on Experience in Cell Culture Techniques.
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Hands on Experience in Cutting-edge Proteomic Technologies.
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I have been granted the title of the outstanding student for the academic year
2003/2004, that I have finished the requirements of graduation within three years and
a half only, taking into consideration that I ranked as the first in my class and my
batch as a whole. Moreover; I have oratory and poetry skills, that I won several prizes
in this respect.
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Also; I’ve been granted the title of the outstanding research and teaching assistant for
the academic year 2005/2006.
Practical Skills
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Molecular Docking (GOLD)
Nuclear Magnetic Resonance (NMR)
MALDI TOF
ESI and LC-MS/MS
Peptide Synthesis
Electrophoresis Techniques
Techniques of Protein Purification
Preperative and Analytical Chromotography Techniques
Cell Culture Techniques
Atomic Force Microscopy
Electron Microscopy
Work Experience and Training
1- Assistant Professor at Al-Isra University, Currently. Teaching Medicinal Chemistry,
Drug Design and Instrumental Analysis.
2- Part-time Lab instructor in Physical Pharmacy, Medicinal Chemistry and Analytical
Chemistry at The University oh Manchester 2008-2012.
3- Senior Pharmacist in Community and hospital pharmacies 2006-2008.
4- Lab. instructor and research assistant in Pharmacology and Toxicology and Medicinal
Chemistry at Al-Isra University 2004-2006.
Individual Projects Executed
 PhD Project:
My PhD project was focused on ways to treat Alzheimer’s disease and the abstract of
my thesis is shown below.
The pathogenesis of Alzheimer’s disease (AD) is mainly correlated to the misfolding
and aggregation of the beta-amyloid peptide. This causes extracellular amyloid-beta
peptide deposition as monomers, oligomers, fibrils and plaques in the brain.
Compounds that may covalently interact with amyloid-beta protein might have a role in
altering the pathogenesis of AD. Some beta-lactam antibiotics (e.g. amoxicillin), orlistat,
resveratrol, vanillin, o-vanillin and ethyl vanillin have been shown to modulate the
process of amyloid-beta peptide aggregation using a range of techniques.
Several approaches have been used to investigate modulation of amyloid-beta peptide
by these compounds. These methods include molecular modelling using both covalent
and non-covalent docking, investigation of covalent interaction by MALDI and LCMS/MS mass spectrometry, and synthesis of model peptides representing key motifs in
the amyloid-beta peptide, aggregation studies of amyloid-beta peptide by using the
thioflavin T (ThT) fluorescence assay, studying the morphology of aggregation by
atomic force microscopy (AFM), and investigating their ability to inhibit amyloid-beta
peptide cell toxicity by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
(MTT) cell toxicity assay.
 B.Sc Graduation Project, 2004:
Al-Isra University, Amman
Duration: 4 months
It was in the last year of under-graduation studies; I have designed a prodrug system
for several poorly bioavailable neurotransmitters such as dopamine and GABA. This
work was definitely directed and advised by highly qualified professors in the faculty.
Languages
Fluent in English, Arabic and average knowledge in French.
Publications:
1-
Semreen, M. H.; El-Shorbagi and Alsalahat, I. M. M., Usage of the Carrier 3,5Disubstituted Tetrahydro-2H-1,3,5-Thiadiazine-2-Thione (THTT) in Designing a
Prodrug System for Poorly Stable Neurotransmitters (2004). Presented at the Fifth
Jordanian Pharmaceutical Conference Amman, Jordan, August 3-5, 2004
2-
Semreen, M. H.; El-Shorbagi, A.; Al-Tel, H. and Alsalahat, I. M. M., Journal of
Medicinal Chemistry, Targeting γ-Aminobutyric Acid (GABA) Carriers to the Brain:
Potential Relevance as Antiepileptic Pro-Drugs, 2010 (6) 144-149.
3-
IM Alsalahat, Z Al-Majdoub, J Barber, N Bruce, RA Bryce, AJ Doig, S Freeman
(2010). Potential covalent modification of amyloid-beta protein with food additives and
medicines and their effect on aggregation. Presented at Interfacing Chemical Biology
and Drug Discovery, 46th International Conference on Medicinal Chemistry. Reims,
France, June 30 - July 2, 2010. eScholarID:83984.
4-
IM Alsalahat, Z Al-Majdoub, J Barber, N Bruce, RA Bryce, AJ Doig, S Freeman
(2010). Potential covalent modification of amyloid-beta protein with food additives and
medicines and their effect on aggregation. Presented at The Ninth Annual World
Pharmaceutical Congress, Successful Targeting of Alzheimer's Disease.
Philadelphia, Pennsylvania USA, June 14-16 2010 eScholarID:83981
5-
IM Alsalahat, Z Al-Majdoub, J Barber, N Bruce, RA Bryce, AJ Doig, S Freeman,
Vanilla Derivatives, Covalent modifiers of amyloid-beta protein, Pending
Submission.
6-
IM Alsalahat, Z Al-Majdoub, J Barber, N Bruce, RA Bryce, AJ Doig, S Freeman,
Potential Covalent Modification of Alzheimer’s Disease by Resveratrol, Orlistat and
amoxicillin, Submitted for publication