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Job Description
Job Title:
Postdoctoral Research Assistant (Medicinal Chemist)
Line Manager:
Prof. S A Ward
Job Aim:
To work with a team of biologists, pharmacologists and
medicinal chemists (including Scientists at the University of
Liverpool supervised by Prof P O’Neil) involved in the
discovery and development of novel peroxide drug
candidates targeting malaria.
Competencies:
Experience in Organic Chemistry/ Medicinal Chemistry.
Summary of role:
The successful applicant will be part of a small chemistry
team involved in organic synthesis, medicinal chemistry and
chromatographic separations and purification
Main duties:
 Take a leading role in the generation of novel routes of synthesis of peroxide
based chemical entities towards the project’s milestones/deliverables
 Design and synthesis of target compounds identified within the group using
heterocyclic/aromatic synthetic chemistry approaches
 Monitor literature for application of best practices and methodologies
 Responsible for the accurate recording, dissemination and archiving of chemistry
data in line with industry standards
 Take a role in the preparation and writing of scientific reports and peer-reviewed
publications
 Assisting with the daily running of the medicinal chemistry facilities
 Perform 1H/13C NMR and LC MS and HPLC
 Responsible for the preparation, maintenance and communication of
methodologies and data to other members of the group
 Responsible for working in a safe manner adhering to local and legal
requirements
 Any other duties commensurate with the role
Person Specification
Post-doctoral Research Assistant (Medicinal Chemist) Ref 283
Essential
Desirable
Education & Training
PhD in Chemical Sciences
Some knowledge of basic
pharmacology
Experience
Extensive experience in
synthetic organic chemistry
Molecular modelling
expertise
Experience in endoperoxide
synthesis, handling reactive Publication record in high
peroxide intermediates
impact Chemistry/
Pharmacology journals.
Knowledge of antimalarial
drug development
Experience of working in
Training in the
the industry/pharma
development of SAR for
biologically active
compounds
Publication record in
Chemistry/Pharmacology
journals
Relevant experience of
working within a research
laboratory
Well developed research
skills with the ability to
present research findings in
oral or written format
Working to targets and
deadlines
Skills & Abilities
Organic synthesis,
purification techniques
such as silica gel
Parallel synthesis
techniques and use of
microwave reactors
chromatography and HPLC
methods
Knowledge of asymmetric
synthesis and
stereochemical control
Ability to generate research
ideas
Excellent communication
skills (both written and
verbal) with the ability to
communicate at all levels
Excellent organisational
skills
Computer literate with
knowledge of Microsoft
Office applications
Team player
Flexible attitude to work
Knowledge
Knowledge of modern
medicinal chemistry and
chemistry
Knowledge of safety
regulations
Knowledge of translational
science and drug discovery
and development
Special Aptitudes
Enthusiastic approach to
work
Ability to work as an
integral and co-operative
member of a multidisciplinary research team
Ability to use initiative and
work independently
Circumstances
Display leadership
qualities