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CLUB DRUGS DANCE ‘TILL YOU DROP MAJOR CLUB DRUGS • • • • • • MDMA/ECSTASY GHB/GBL KETAMINE NITROUS OXIDE POPPERS LSD MISCELLANEOUS DRUGS • • • • • 2C-B GBL – GAMMA BUTYL LACTONE DEXTROMETHORPHAN HERBAL ECSTASY MUSHROOMS ESCTASY • MDMA • • • • • • • • METHYLENEDIOXYMETHAMPHETAMINE ADAM X-TC CLARITY ESSENCE STACY LOVER’S SPEED EVE DOSAGES • THRESHOLD – 30 MG • AVERAGE – 75-125 MG • LETHAL DOSE – 106 - ~ 6000MG MDMA ACTIONS • DURATION • PRIMARY EFFECTS 3-4 HRS • “CRASH” 2-6 HRS • HANGOVER – (MAY LAST UP TO 5 DAYS) • POST –MDMA DEPRESSION MECHANISM OF ACTION • • • • DECREASES DOPAMINE RELEASE INHIBITS REUPTAKE OF SEROTONIN RELEASES SEROTONIN RESEMBLES HYBRID AMPHETAMINE & MESCALINE COMMON CONTAMINANTS • • • • • • • CHALK LSD AMPHETAMINES HEROIN CAFEINE KETAMINE EPHEDRINE ECSTASY BEHAVIORAL EFFECTS • • • • • • • • • INCREASED ENERGY EMPATHY TOWARD OTHERS INCREASED AFFECTION EMOTIONAL OPENNESS PROFOUND POSITIVE FEELINGS EUPHORIA DECREASED INHIBITIONS DECREASED ANXIETY EXTREME RELAXATION MDMA ACUTE EFFECTS • • • • • • • • TEETH CLENCHING NAUSEA HALLUCINATION CHILLS SWEATING TREMORS BLURRED VISION MUSCLE CRAMPING ACUTE SIDE EFFECTS • HYPERTHERMIA – INCREASED BODY TEMPERATURE • DEHYDRATION • CARDIOVASCULAR STIMULATION METABOLIC ACIDOSIS • RHAMDOMYOLOSIS – MUSCLE BREAKDOWN ACUTE TOXICITY • HYPERTHERMIA • CONVULSIONS • DISSEMINATED INTRAVASCULAR COAGULATION • ACUTE RENAL FAILURE • CARDIAC ARRYTHMIAS • HEPATITIS MDMA OVERDOSE • HIGH BLOOD PRESSURE • FAINTNESS • PANIC ATTACKS • LOSS OF CONSCIOUSNES S • SEIZURES • HEART FAILURE • HEAT STROKE MDMA AFTER EFFECTS • ANXIETY • PARANOIA • DEPRESSION MDMA PERMANENT DAMAGE • • • • • • DEPRESSION ANXIETY MEMORY LOSS CHANGES IN SLEEP PATTERNS LEARNING IMPAIRMENTS EMOTIONAL PROBLEMS MDMA TOXICITY • SIMILAR TO HEAT STROKE • URINARY pH LESS THAN 5.6 IN METABOLIC ACIDOSIS • CAUSES MYOGLUBIN CASTS • HYPERKALEMIA RELATED TO CARDIAC ARRYTHMIA • WATER INTOXICATION NEUROTOXICITY • NEURONAL DAMAGE • DECREASE IN DOPAMINE • LOSS OF SEROTONIN NERVE TERMINALS • PARKINSONISM • APPETITE SUPPRESSION PROTECTIVE MEASURES? • VIAGRA FOR SEXUAL PROBLEMS • SSRIs e.g. PROZAC • DRUGS THAT BLOCK DA RELEASE • ANTIOXIDANTS GHB • • • • • • • • GAMMA HYDROXYBUTYRATE LIQUID X, GREVIOUS BODILY HARM CNS DEPRESSANT ALSO USED BY BODY BUILDERS SALTY TASTING LIQUID ONSET OF ACTION 10-20 MIN EFFECTS LAST UP TO 4 HOURS CLEARED QUICKLY GHB USES • • • • • • INTOXICATING PROPERTIES SEDATIVE ACTIONS EUPHORIC EFFECTS RELIEVE ANXIETY PRODUCE RELAXATION GH RELEASING PROPERTIES GHB OVERDOSE • • • • • • • DROWSINESS NAUSEA/VOMITING HEADACHE LOSS OF CONSCIOUSNESS LOSS OF REFLEXES IMPAIRED BREATHING COMA/DEATH GHB DANGERS • • • • • • • • DROWSINESS DIZZINESS NAUSEA UNCONSCIOUSNESS SEIZURES SEVERE RESPIRATORY DEPRESSION COMA DEATH GHB WITHDRAWAL • • • • ANXIETY RESTLESSNESS INSOMNIA RAPID HEART BEAT • NAUSEA GHB DEATH LIST KETAMINE • • • • • • • SEDATIVE-HYPNOTIC SPECIAL k & k GENERAL ANESTHETIC HALLUCINOGEN ANALGESIC RAPID ONSET LASTS ~ ONE HOUR KETAMINE EFFECTS • • • • • • • • IMPAIRED COORDINATION IMPAIRED JUDGEMENT PERISTENT MEMORY PROBLEMS PSYCHOTIC SYMPTOMS DREAMLIKE STATES HALLUCINATIONS NEAR DEATH EXPERIENCE (K-HOLE) SENSORY IMPAIRMENT NITROUS OXIDE • • • • LAUGHING GAS DISSOCIATIVE ANESTHETIC AVAILABLE IN “WHIPPITS” INHALED FROM TANK OR BALLOONS • EFFECTS IMMEDIATE & SHORTLIVED NITROUS EFFECTS • EUPHORIA • ANALGESIA • LOSS OF CONSCIOUSNESS ADVERSE EFFECTS • TEMPORARY LOSS OF MOTOR CONTROL • SENSATIONS & PERCEPTIONS DISCONNECTED • DREAMY MENTAL STATE • MILD AUDIO & VISUAL HALLUCINATIONS DANGERS • COLD GAS BURNS LIPS, THROAT, LUNGS • HYPOXIA • LONG-LASTING NUMBNESS IN EXTREMITIES POPPERS AMYL NITRATE/BUTYL NITRATE • • • • • • RELAX SMOOTH MUSCLE PRODUCE FEELING OF “RUSH” FLUSHING DIZZINESS HEADACHE PROGRESSIVE LOSS OF CONSCIOUSNESS LSD • • • • • POTENT HALLUCINOGEN ERGOT FUNGUS 30 g DOSE ONSET WITHIN 30-90 MIN “HIGH” LASTS 6-12 HOURS LSD EFFECTS • • • • • • • • DILATED PUPILS HIGHER BODY TEMPERATURE INCREASED HEART RATE INCREASED BLOOD PRESSURE SWEATING DRY MOUTH TREMORS NUMBNESS/WEKNESS LSD ACTIONS • • • • • • • • DILATED PUPILS INCREASED BODY TEMPERATURE INCREASED HEART RATE INCREASED BLOOD PRESSURE LOSS OF APPETITE INCREASED SWEATING DRY MOUTH TREMORS “BAD TRIP” • • • • • • • • TERRIFYING THOUGHTS SEVERE AGITATION FEAR OF LOSING CONTROL FEAR OF INSANITY & DEATH SEVERE ANXIETY SUICIDAL THOUGHTS PRECIPITATE PSYCHOSIS ACCIDENTAL DEATH LSD PSYCHOSIS • AFFECT PERCEPTION OF REALITY • INABILITY TO THINK RATIONALLY • DRAMATIC MOOD SWINGS • VIVID VISUAL DISTURBANCES • HALLUCINATIONS HALLUCINOGEN PERSISTING PERCEPTION DISORDER (HPPD) • • • • • • • EPISODIC VISUAL DISTURBANCES “FLASHBACKS” FALSE FLEETING PERCEPTIONS FLASHES OF COLOR GEOMETRIC PSEUDOHALLUCINATIONS POSITIVE AFTERIMAGES PERMANENT ALTERATION IN VISUAL SYSTEM PCP • • • • • • • DEVELOPED IN 1950 WAS USED AS IV ANESTHETIC DISSOCIATIVE “OUT OF BODY” PRODUCES DELIRIUM EXTREME AGITATION RAPID ONSET LASTS FOR SEVERAL HOURS PCP ACTIONS • DISRUPTS NMDA RECEPTORS • AFFECT GLUTAMATE ACTIVITY • GLUTAMATE ROLE IN PAIN, COGNITION, LEARNING & MEMORY • ALSO AFFECTS DA CAUSING EUPHORIA OR “RUSH” PCP EFFECTS • • • • • • • SHALLOW RAPID BREATHING INCREASED BLOOD PRESSURE INCREASED HEART RATE ELEVATED TEMPERATURE NAUSEA BLURRED VISION DECREASED PAIN AWARENESS PCP EPISODE • • • • • • • DETACHEMENT FROM REALITY DISTORTION OF TIME/SPACE ALTERED BODY IMAGE FEELING INVULNERABLE EXAGGERATED STRENGTH SEVERE DISTORIENTATION SUICIDAL BEHAVIOR DEXTROMETHORPHAN • OTC COUGH MEDICINE • NMDA ANTAGONIST • DISSOCIATIVE EFFECTS ROHYPNOL • • • • • FLUNITRAZEPAM ROOFIES ILLEGAL IN US TASTELESS/ODORLESS 1 MG DOSE LASTS 8-12 HOURS ROHYPNOL ACTIONS • SEDATIVE EFFECTS 10X THAN VALIUM • EFFECTS APPEAR 15-20 MIN • LAST 4-6 HOURS • RESIDUAL EFFECTS UP TO 12 HOURS ROHYPNOL USES • • • • • BOOST HIGH FROM ALCOHOL BOOST HIGH FROM HEROIN MODULATE COCAINE EFFECTS RAVE DRUG “DATE RAPE” DRUG ROHYPNOL ADVERSE EFFECTS • • • • • • • • LOSS OF MOTOR CONTROL LACK OF COORDINATION SLURRED SPEECH CONFUSION GI DISTRESS RESPIRATORY DEPRESSION IMPAIRED COGNITION AMNESIA METHAMPHETAMINE EFFECTS • • • • • MEMORY LOSS VIOLENCE PSYCHOTIC BEHAVIOR CARDIAC ARRYTHMIAS NEUROLOGICAL DAMAGE METH TOXICITY • REDUCTION IN DA TRANSPORTERS • MASSIVE RELEASE OF DA & NE END • HIT ESCAPE TO END • CLICK HERE TO REPEAT