Download 26 120 515 Molecular Biology of Eukaryotes

Course Syllabus/Fall 2012
120:515 Molecular Biology of Eukaryotes
INSTRUCTORS:
OFFICE/OFFICE
HOURS:
COURSE
LOCATION(S):
Alexis J. Rodriguez, Ph. D.
Nan Gao, Ph. D.
Robert Delotto, Ph. D.
EMAIL:
[email protected]
LSC 601C
COURSE
WEBSITE:
Blackboard
MEETING TIME(S): TUES, THUR 4:00 – 5:30 PM
Englehard 215
COURSE DESCRIPTION:
First-year graduate course providing an accelerated review of eukaryotic molecular biology. Introduces critical
reading and discussion of current journal articles. Nucleic acid biochemistry, molecular technology, transcription,
RNA processing, chromosomal structure, molecular anatomy of the genome, genomic rearrangements, gene
control signals, DNA-protein binding, carcinogenesis, and oncogenes
PREREQUISITES:
Undergraduate Molecular Biology and Biochemistry
REQUIRED TEXT:
Nancy Craig et al., Molecular Biology: Principles of Genome Function
LEARNING OBJECTIVES/GOALS: FOR EXAMPLE
Upon successful completion of this course, participants will be able to:
1. Describe how the structure of DNA, RNA, Proteins, Lipids, and Carbohydrates contributes to their
specific functions.
2. Describe the central dogma of the flow of genetic information.
3. Describe the intermolecular forces used to promote interactions between DNA, RNA, Proteins,
Lipids, and Carbohydrates.
4. Discuss the roles of non-coding RNAs in regulating gene expression.
5. Describe how DNA, RNA, and Proteins are synthesized, regulated, and degraded in cells.
6. Describe the current state of Molecular Biology research through reading and analyzing primary
research manuscripts.
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Course Syllabus/Fall 2012
120:515 Molecular Biology of Eukaryotes
SCHEDULE AND COURSE OUTLINE: Dates listed by week; lectures will meet twice every week and recitation will meet every
week, unless otherwise noted. Weekly dates of quizzes and due dates for written projects are listed, but please note there
will be additional smaller assignments throughout the semester. Due dates for these assignments will be regularly updated
on the course Blackboard site.
WEEK
Week 1
Week 2
Week 3
Week 4
NOTES/READING
ASSIGNMENTS/EXAMS
MEETING TOPIC
Central dogma of the flow of genetic information &
Nucleic Acid Structure I
Nucleic Acid Structure II & Protein Structure and Function
I
Protein Structure and Function II & Biological Chemistry
and Thermodynamics I
Biological Chemistry and Thermodynamics II &
Chromosome Structure and Function I
Chapters 1 & 2
Chapter 2
Chapters 2 & 3
Chapters 3 & 4
Week 5
Chromosome Structure and Function II & Exam I
Chapter 4 & Chapters 1-4
Week 6
Transcription I & II
Chapter 8
Week 7
Transcription Journal Club & RNA Processing
Assigned Manuscripts & Chapter 9
Week 8
RNA Processing Journal Club & Translation I
Assigned Manuscripts & Chapter 10
Week 9
Translation II & Translation Journal Club
Chapter 10 & Assigned Manuscripts
Week 10
Exam II & Protein Modification
Chapters 8-10 + Assigned Manuscripts &
Chapter 11
Week 11
Protein Trafficking Journal Club & Protein Modification
and Trafficking Journal Club
Assigned Manuscripts
Week 12
Non Coding RNAs I & II
Assigned Manuscripts
Week 13
Non Coding RNAs Journal Club & Molecular Biotechniques
Assigned Manuscripts & Chapter 16
Week 14
Molecular Biotechniques
Chapter 16
Week 15
Molecular Biotechniques
Assigned Manuscripts
DATE OF FINAL EXAM: 12/18/2012
GRADING POLICY:
Your grade for this course will be determined based on the categories listed in the table below.
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Point Values
Each Exam is worth 33.3% of the final grade
Point Values
Point Values
Point Values
Point Values
Point Values
TOTAL
Total Points
ATTENDANCE, MAKE-UP, AND LATENESS POLICY:
Attendence is highly encouraged. If you must miss class for a valid reason, please discuss making up the missed material
with your instructor as soon as possible. All late Assignments will have 10 points deducted per week.
Academic Dishonesty: The course has a zero tolerance policy for academic dishonesty, including plagiarism and cheating.
Instances of dishonesty will be punished by a zero on the assignment and consultation with the Academic Integrity Officers
to determine if further action is required. If you have any questions about what constitutes plagiarism or cheating, please
ask your instructors or refer to the academic integrity websites for Rutgers and NJIT:



http://academicintegrity.rutgers.edu/academic-integrity-at-rutgers
http://studentconduct.rutgers.edu/
http://www.njit.edu/academics/integrity.php
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