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Oh The Possibilities!
A Close Look at Human Inheritance Patterns
Procedure
1. Determine your genotypes for the traits listed on the table. If you’re unsure, flip a coin to
determine the dominant or recessive allele. (Heads = dominant)
2. Each parent should obtain a normal male and female karyotype. (Preferably, one male
and one female per group)
3. Transfer your genotypes from Table 1 onto your karyotype. Locate each gene pair on
the appropriate chromosome (see Table 1) on your human karyotype. For example, if
you are heterozygous (Bb) for the trait on chromosome pair 2, you should label one of the
chromosomes with "B" and the other chromosome with "b". (Underline ALL dominant
alleles). Since these chromosomes have gone through duplication in preparation for
division, each chromatid has the allele (see below).
B B b b
4. Obtain a blank “Baby Karyotype.”
5.
To create your baby’s karyotype, cut out your chromosomes, along with the
chromosomes from your mate and glue them on the “Baby Karyotype.” Choose the
chromatids by doing the following meiosis simulation.
a. Flip a coin to determine which chromosome from a given pair will be passed onto
the child; heads = chromosome on left; tails = chromosome on the right.
b. Meiosis 1: Cut out the chromosome you flipped for, being careful to also cut out
the symbols for the genes that you put on the chromosomes.
c. Meiosis 2: Cut the duplicated chromosome in half and place one of the pieces on
the Baby Karyotype above the appropriate chromosome number. Your mate
should do the same thing, resulting in a pair of single separate chromosomes, one
from Mom and one from Dad.
d. Continue this process for every pair of chromosomes until an entire baby karyotype
is produced with 23 pairs of single chromosomes.
6. After completing the baby’s karyotype, determine your child’s genotype and phenotype
for each of the traits and record in the chart provided.
7. Name your baby and create a sketch (avatar) of the child. The name should be a
combination of both parents.
Oh The Possibilities!
A Close Look at Human Inheritance Patterns
Individual Genotypes
Table 1
TRAIT
Chromosome
for gene
location**
Skin cancer
Face shape
1
1
Hair color
2–B
15 - C
16 - D
17 – E
3
3
4
(natural)
Widow’s peak
Lung cancer *
Cheek
dimples
Skin color
5
(natural)
Face freckles
Red hair color
Mouth size
6
6 (only if < 4
dominant hair
color)
7
Cystic fibrosis
Eyebrow
length
Nose shape
7
8
Ear lobes
Albinism
Tongue rolling
Cleft chin
Blood type
10
11
11
12
12
Hair type
13
9
(natural)
Eye color
14
(natural)
Dominant
Phenotype
Possible
Dominant
Genotypes
Normal
Round
Heart shape
Black
Dark brown
Light brown
CC or Cc
AA
Aa
8 d. alleles
5 to 7 d. alleles
3 to 4 d. alleles
Skin cancer
Square
cc
aa
Blonde
White
1 or 2 d. alleles
0 dom. alleles
Peak
Normal
Dimples
DD or Dd
NN or Nn
EE or Ee
No peak
Lung cancer
No dimples
dd
nn
ee
Dark
Medium
Freckles
Red tint
FFGG / FfGg
Ffgg / ffGg
GG or Gg
TT or Tt
Light
ffgg
No freckles
No red tint
gg
tt
Long
Average
Normal
Not
connected
Rounded
Straight
Free
Normal
Ability
Cleft
A, B, or AB
HH
Hh
CC or Cc
II or Ii
Short
hh
C.F.
Connected
cc
ii
Pointed
jj
Attached
Albino
No ability
No cleft
O
kk
aa
ll
mm
OO
Curly
Wavy
Brown
Green
Normal
JJ
Jj
KK or Kk
AA or Aa
LL or Ll
MM or Mm
AA, AO, BB, BO,
AB
NN
Nn
PPQQ/PPQq
ppQQ / PpQq
XX or Xx
Straight
nn
blue
ppqq
xx
YY
Yy
RR
Rr
SS
Ss
TT or Tt
Xeroderma
pigmentosa
Short
Far apart
rr
Thin
ss
Crooked
tt
Muscular
Dystrophy
Colorblind
m
Xerderma
pigmentosa
Eye lashes
18
Eye distance
20
Lip thickness
21
Teeth (before
22
Long
Average
Close
Average
Thick
Normal
Straight
23 (x only)
Normal
M
23 (x only)
Normal
C
19
Recessive
Phenotype
Recessive
Genotype
yy
braces)
Muscular
Dystophy
Color
blindness
c
**The gene locations for all of the traits are not known yet so these numbers are arbitrary.
Your
Genotype
Name:______________________
Oh The Possibilities!
Mate: ______________________
A Close Look at Human Inheritance Patterns
Analysis -Individual
A. Write a summary about “Oh the Possibilities.” Include what you learned from this lab, your
enjoyment (or lack there of) of the lab, and any other thoughts you had while completing the lab.
The reflection must be a minimum of 5 paragraphs that use complete sentences. The summary
must be typed to earn the credit.
Paragraphs
1. Introduce yourself, mate and child and any unique attributes
2. How does the process simulate making a baby?
3. Describe the benefits/limitations of knowing your actual genotypes. Would you really
want to know what specific traits you have?
4. Choose a genetic disorders or disease that was present in this activity and write a
paragraph describing the disease. (Site your source)
5. Summarize the activity; did you enjoy it, problems encountered, and the main ideas
learned.
B. Develop five different genetic crosses based upon your genotypes. Determine the probability (%)
of the trait your baby has. The five types of crosses should include:
1. Simple Monohybrid (Dimples)
2. Multiple Allele (Blood Type)
3. Sex-linked (muscular dystrophy)
4. Polygenic (skin color)
5. Dihybrid cross ( Eye Distance and Eyebrow length)
Rubric
GROUPS COMPONENTS
________ (10 pts) The karyotype your child.
________ (10 pts) A table listing the genotypes and phenotypes of the child.
________(10 pts) A sketch of the teen-aged child showing ALL the phenotypes that are expressed. Get
creative! The sketch should include the name of the child.(or use a computer avatar
maker)
INDIVIDUAL COMPONENT
________ (20 pts) The typed summary from your lab.
________ (20 pts) 5 Genetic Crosses
TOTAL SCORE: ____________________________ / 70pts
Oh The Possibilities!
A Close Look at Human Inheritance Patterns
Oh The Possibilities!
A Close Look at Human Inheritance Patterns