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WHAT IS THE CENTER FOR PERSONALIZED DIAGNOSTICS? (CPD) FAQ: The CPD aims to uncover genetic mutations within a patient’s own cancer that can allow for a more targeted and personalized “precision” treatment strategy. The CPD is a joint program and collaboration between Penn’s Department HOW PENN’S PERSONALIZED DIAGNOSTICS CAN HELP of Pathology and Laboratory Medicine and the Abramson I F Y O U A R E A C A N C E R P AT I E N T Cancer Center. That means our pathologists work hand-inhand with your oncologist to determine the best course of action for your cancer treatment, based on the genomic test results and your specific needs. “ “ Armed with Personalized Diagnostics, physicians can apply This is the key to personalized ‘precision’ medicine. – D avid B. Roth, MD, PhD Simon Flexner Professor of Pathology and Laboratory Medicine Director, Penn Center for Precision Medicine FY16-11178 07/16 genetic findings in a proactive way to tailor cancer treatments. The Center for Personalized Diagnostics PennMedicine.org/CPD WHAT IS PERSONALIZED OR PRECISION MEDICINE? Personalized medicine aims to individualize treatments to match each patient with the therapy they are most likely to respond to by assessing the patients’ unique genomic alterations or background. This allows your medical team to more precisely deliver the right treatment, to the right person, at the right time. WHAT DOES CANCER HAVE TO DO WITH GENOMIC ALTERATIONS? Cancer is just normal cells that have acquired genetic mutations that make those cells become “cancer” cells. (See graphic below) DOES IT REQUIRE ANOTHER PROCEDURE? Only your oncologist can order a CPD test. To have your cancer tested by the CPD usually does not require another procedure. Your oncologist will request your sample to be sent directly to the lab for analysis. HOW CAN THE CPD HELP ME? The CPD can help find those exact genomic alterations that turned your healthy cells into cancer cells and can be targeted to help eliminate them. WHAT IS THE LIKELIHOOD THE CPD WILL IDENTIFY A TARGETED TREATMENT FOR ME? In clinical cases, disease-associated mutations have been reported in 75% of patient tests which may reveal results with therapeutic significance. Though the mutations can be useful for better understanding your cancer, the mutations often do not have a treatment to match the particular mutation. The clinical relevance of the findings associated with CPD testing will be discussed by your oncologist. WHO SHARES THE RESULTS WITH ME AND HOW LONG WILL IT TAKE TO RECEIVE THEM? Your oncologist will share your results with you and review what the next steps are for your treatment. Depending on what tests are ordered, results are usually received within 7-14 days. HOW MUCH DOES CPD COST AND WILL MY INSURANCE COVER IT? The CPD is committed to providing patients, clinicians and healthcare professionals with high quality and affordable oncology testing. The CPD accepts all private insurances and Medicare. Our complete billing policy is listed on the CPD web site, PennMedicine.org/CPD. HOW CAN KNOWING MY GENOMIC ALTERATIONS POSSIBLY HELP MY CANCER TREATMENT? The most important result of Precision Medicine is that it can help to identify targeted therapies that may be more effective and have less side effects, based on the patient’s individualized cancer mutations. Knowing genomic cancer alterations may also spare some individuals the costs and side effects of targeted therapies. Knowing your genomic alterations may also provide a rationale for matching your results with molecularly targeted therapies in clinical trials. Your oncologist will discuss these options if they apply. CANCER GENOMIC ALTERATIONS & THE CPD QUESTIONS? HEALTHY cell ENVIRONMENTAL EXPOSURE or some other agent causes mutations in cell’s DNA MUTATIONS turn the healthy cells into “Cancer” cells, which multiply, live forever CPD lets us find the exact mutations that turned these cells into cancer, so that available treatments targeted at those exact mutations can be tried You should first ask your oncologist for specific questions you have regarding testing at CPD. Learn more at Penn Medicine.org/CPD.